Breast Cancer Clinical Trials

78 trials recruiting in Canada.

Cancer

Recruiting Drug Device Behavioral Older adults Healthy volunteers

78 trials · showing 30

Testing Ribociclib with Letrozole for early breast cancer

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Sites in Montreal, Toronto and 6 more cities

RecruitingPHASE3

Official title: Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Early Breast Cancer · Novartis Pharmaceuticals

Comparing 7 approaches for breast cancer

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Sites in Toronto and Vancouver

RecruitingPHASE1

Official title: A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

Breast Cancer · Eli Lilly and Company

Comparing 4 approaches for breast cancer

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One site, in Toronto

RecruitingPHASE1

Official title: A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

Breast Cancer · Genentech, Inc.

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Testing LY4064809 against a placebo for breast neoplasms

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Sites in Hamilton, Québec and 2 more cities

RecruitingPHASE3

Official title: A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Breast Neoplasms · Eli Lilly and Company

Testing Inavolisib with Ribociclib against a placebo for breast cancer

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Sites in Chicoutimi, Montreal and 2 more cities

RecruitingPHASE2

Official title: A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Breast Cancer · Hoffmann-La Roche

Comparing Radiation and Endocrine Therapy with Endocrine Therapy (Tamoxifen, for stage i breast cancer

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Sites in Kingston, Montreal and 5 more cities

RecruitingPHASE3

Official title: De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Stage I Breast Cancer · NRG Oncology

Testing Dual-Energy Contrast-Enhanced Spectral for breast cancer

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One site, in London

Recruiting

Official title: Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

Breast Cancer · American College of Radiology

Comparing Lasofoxifene in combination with with Fulvestrant in combination with for metastatic breast cancer

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Sites in Montreal, Ottawa and 2 more cities

RecruitingPHASE3

Official title: Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Metastatic Breast Cancer · LeonaBio

Comparing Ovarian Function Suppression + with Adjuvant Chemotherapy + Ovarian for breast cancer

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Sites in Montreal, Barrie and 9 more cities

RecruitingPHASE3

Official title: Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Breast Cancer · NRG Oncology

Testing Definity with Sonalleve Focused Ultrasound Device for breast cancer

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One site, in Toronto

RecruitingPHASE2

Official title: Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer

Breast Cancer · Sunnybrook Health Sciences Centre

Comparing Zanidatamab with Trastuzumab for metastatic HER2-positive breast cancer

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Sites in Montreal, Ottawa and 3 more cities

RecruitingPHASE3

Official title: A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Metastatic HER2-positive Breast Cancer · Jazz Pharmaceuticals

Comparing 3 approaches for breast neoplasms

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Sites in Montreal, Kingston and 1 more city

RecruitingPHASE1

Official title: Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

Breast Neoplasms · Merck Sharp & Dohme LLC

Comparing Multiple Fraction PBI with Single Fraction PBI for breast cancer early stage breast cancer (stage 1-3)

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One site, in Prince George

Recruiting

Official title: Single vs Hypofractionated Irradiation For Timely Access to Partial Breast Radiotherapy

Breast Cancer Early Stage Breast Cancer (Stage 1-3) · British Columbia Cancer Agency

Comparing 3 approaches for breast cancer

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Sites in Calgary, Kitchener and 1 more city

RecruitingPHASE1

Official title: A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

Breast Cancer · Pfizer

Comparing 7 approaches for breast cancer

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Sites in Montreal, Toronto and 1 more city

RecruitingPHASE2

Official title: A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Breast Cancer · Hoffmann-La Roche

Comparing Palazestrant with Letrozole for breast cancer

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One site, in Toronto

RecruitingPHASE3

Official title: Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Breast Cancer · Olema Pharmaceuticals, Inc.

Comparing 5 approaches for breast neoplasms

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Sites in Toronto, Hamilton and 1 more city

RecruitingPHASE1

Official title: A Study of LY4257496 in Participants With Cancer (OMNIRAY)

Breast Neoplasms · Eli Lilly and Company

Comparing Axillary lymph node dissection with Axillary radiotherapy for breast cancer

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One site, in Montreal

Recruiting

Official title: Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

Breast Cancer · University Hospital, Basel, Switzerland

Testing Radiation with Pembrolizumab (KEYTRUDA®) for breast cancer

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2 sites in London

RecruitingPHASE2

Official title: Neoadjuvant, SBRT With Intratumoural Pembrolizumab Followed by Neoadjuvant Chemotherapy in Breast Cancer

Breast Cancer · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Comparing 4 approaches for metastatic breast cancer

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Sites in Kitchener, Ottawa and 1 more city

RecruitingPHASE4

Official title: Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic Breast and Prostate Cancers

Metastatic Breast Cancer · Ottawa Hospital Research Institute

Testing Quantitative ultrasound to guide for breast cancer

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One site, in Toronto

Recruiting

Official title: Use of Quantitative Ultrasound to Guide Adaptive Chemotherapy Among Women With Breast Cancer

Breast Cancer · Sunnybrook Health Sciences Centre

Comparing Trastuzumab with Pertuzumab for breast cancer

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Sites in Hamitlon, Ottawa and 1 more city

RecruitingPHASE2

Official title: Safety of Continuing HER-2 Directed Therapy in Overt Left Ventricular Dysfunction

Breast Cancer · Population Health Research Institute

Testing 4FMFES-PET for ER+ breast cancer

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One site, in Sherbrooke

RecruitingPHASE2

Official title: 4FMFES-PET Imaging of ER+ Advanced Breast Cancers

ER+ Breast Cancer · Centre de recherche du Centre hospitalier universitaire de Sherbrooke

Comparing No endocrine therapy with Endocrine therapy for breast cancer

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Sites in Edmonton, Kitchener and 6 more cities

RecruitingPHASE4

Official title: Evaluating Harms and Benefits of Endocrine Therapy in Patients ≥70 Years of Age With Lower Risk Breast Cancer

Breast Cancer · Ottawa Hospital Research Institute

Testing Single Pre-Operative Radiation Therapy for breast cancer

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2 sites in Montreal

Recruiting

Official title: Single Pre-Operative Radiation Therapy - With Delayed or No Surgery (SPORT-DNS)

Breast Cancer · Maisonneuve-Rosemont Hospital

Comparing Whole Breast Irradiation with Partial Breast Irradiation for breast neoplasm female

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Sites in Montreal, Toronto and 14 more cities

RecruitingPHASE3

Official title: A Randomized Trial of Five Fraction Partial Breast Irradiation (RAPID2)

Breast Neoplasm Female · Ontario Clinical Oncology Group (OCOG)

Comparing 7 approaches for breast cancer

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Sites in Toronto, Calgary and 7 more cities

RecruitingPHASE2

Official title: Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer

Breast Cancer · Canadian Cancer Trials Group

Comparing 3 approaches for breast cancer

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Sites in Montreal, Calgary and 5 more cities

RecruitingPHASE3

Official title: A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

Breast Cancer · Hoffmann-La Roche

Comparing Tamoxifen with Camizestrant for early breast cancer breast cancer

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Sites in Montreal, Barrie and 10 more cities

RecruitingPHASE3

Official title: A Study of Camizestrant in ER+/HER2- Early Breast Cancer After at Least 2 Years of Standard Adjuvant Endocrine Therapy

Breast Cancer, Early Breast Cancer · AstraZeneca

Comparing Surgical Intervention with Conservative Complex Physical for breast cancer lymphedema

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Sites in Montreal and Vancouver

Recruiting

Official title: The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema

Lymphedema, Breast Cancer · University Hospital, Basel, Switzerland

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.