Colorectal Cancer Clinical Trials

37 trials recruiting in Canada.

Cancer

Recruiting Drug Device Behavioral Older adults Healthy volunteers

37 trials · showing 30

Comparing 3 approaches for metastatic colorectal cancer

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Sites in Ottawa and Toronto

Official title: A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)

Metastatic Colorectal Cancer · EMD Serono Research & Development Institute, Inc.

Comparing Drug: Ivonescimab with Drug: Bevacizumab for metastatic colorectal cancer (CRC)

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Sites in Montreal, Regina and 1 more city

RecruitingPHASE3

Official title: Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer (CRC) · Summit Therapeutics

Comparing Prophylactic defect closure with No prophylactic defect closure for colorectal cancer

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One site, in Montreal

Recruiting

Official title: Complete Closure After Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps

Colorectal Cancer · Centre hospitalier de l'Université de Montréal (CHUM)

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Testing Floxuridine for colorectal adenocarcinoma metastatic in the liver

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One site, in Toronto

RecruitingPHASE2

Official title: Hepatic Arterial Infusion Chemotherapy in Patients With Inoperable Colorectal Cancer Liver Metastasis

Colorectal Adenocarcinoma Metastatic in the Liver · Sunnybrook Health Sciences Centre

Comparing 5 approaches for untreated, unresectable, or metastatic colorectal cancer

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Sites in Montreal, Toronto and 4 more cities

RecruitingPHASE2

Official title: A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

Untreated, Unresectable, or Metastatic Colorectal Cancer · Bristol-Myers Squibb

Testing GSK5460025 for colorectal neoplasms

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Sites in Hamilton, Montreal and 1 more city

RecruitingPHASE1

Official title: A Study to Investigate the Safety and Preliminary Efficacy of GSK5460025 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

Neoplasms, Colorectal · GlaxoSmithKline

Testing Radiation Therapy with FOLFOX regimen for colorectal carcinoma

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One site, in Montreal

RecruitingPHASE2

Official title: Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA)

Colorectal Carcinoma · Neil Kopek

Comparing 3 approaches for colorectal cancer

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Sites in Montreal, Ottawa and 1 more city

RecruitingPHASE2

Official title: A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

Colorectal Cancer · Ono Pharmaceutical Co., Ltd.

Comparing 3 approaches for colorectal cancer

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Sites in Montreal and Ottawa

RecruitingPHASE1

Official title: A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Colorectal Cancer · Merck Sharp & Dohme LLC

Testing Sotevtamab with FOLFOX for metastatic colorectal cancer

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One site, in Montreal

RecruitingPHASE2

Official title: Sotevtamab (AB-16B5) Combined With FOLFOX as Neoadjuvant Treatment Prior to Resection of Colorectal Cancer Liver Metastasis

Metastatic Colorectal Cancer · Alethia Biotherapeutics

Comparing Stereotactic Ablative Radiotherapy with Chemotherapy for metastatic colorectal adenocarcinoma

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One site, in Calgary

RecruitingPHASE2

Official title: Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

Metastatic Colorectal Adenocarcinoma · Alliance for Clinical Trials in Oncology

Comparing FIT with Colonoscopy for colorectal polyp

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Sites in Calgary, London and 2 more cities

Recruiting

Official title: Colonoscopy vs Stool Testing for Older Adults With Colon Polyps

Colorectal Polyp · Dartmouth-Hitchcock Medical Center

Testing Embolization for colorectal cancer liver metastases (CRLM)

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Sites in Hamilton, Montreal and 3 more cities

Recruiting

Official title: The DRAGON 2 Trial

Colorectal Cancer Liver Metastases (CRLM) · Maastricht University

Comparing 4 approaches for advanced or metastatic colorectal cancer

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Sites in Ottawa, Toronto and 1 more city

RecruitingPHASE1

Official title: A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Advanced or Metastatic Colorectal Cancer · Janssen Research & Development, LLC

Comparing Full Gadoxetate-enhanced liver MRI with Shortened Gadoxetate-enhanced liver MRI for liver metastasis colon cancer

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2 sites in London

Recruiting

Official title: Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer

Liver Metastasis Colon Cancer · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Comparing tucatinib with bevacizumab for colorectal neoplasms

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Sites in Toronto, Montreal and 2 more cities

RecruitingPHASE3

Official title: A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

Colorectal Neoplasms · Seagen, a wholly owned subsidiary of Pfizer

Comparing 4 approaches for stage III colon cancer

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Sites in Toronto, Montreal and 24 more cities

RecruitingPHASE2

Official title: Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

Stage III Colon Cancer · NRG Oncology

Testing Mobile App for colorectal disorders

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One site, in Toronto

Recruiting

Official title: Home to Stay Mobile App for Colorectal Surgery

Colorectal Disorders · Mount Sinai Hospital, Canada

Testing FOLFOXIRI and Bevacizumab for metastatic colorectal cancer

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One site, in Regina

RecruitingPHASE2

Official title: Conversion From Unresectable To Resectable Metastatic Colorectal Cancer.

Metastatic Colorectal Cancer · University of Saskatchewan

Testing Radical external beam radiotherapy for colorectal carcinoma

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2 sites in Montreal

Recruiting

Official title: Patients With Rectal Cancer: a "Wait-and-see" Approach

Colorectal Carcinoma · McGill University Health Centre/Research Institute of the McGill University Health Centre

Testing live donor liver transplantation for colorectal cancer

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One site, in Toronto

Recruiting

Official title: Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases

Colorectal Cancer · University Health Network, Toronto

Testing INCA33890 with Bevacizumab against a placebo for CRC (colorectal cancer)

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Sites in Toronto, Edmonton and 4 more cities

RecruitingPHASE3

Official title: A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

CRC (Colorectal Cancer) · Incyte Corporation

Comparing 8 approaches for metastatic colorectal cancer

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Sites in Calgary, Edmonton and 3 more cities

RecruitingPHASE2

Official title: A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer · AbbVie

Comparing Volrustomig with FOLFIRI (Fluorouracil (5-FU), for metastatic colorectal cancer

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Sites in Barrie, Montreal and 2 more cities

RecruitingPHASE2

Official title: A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Metastatic Colorectal Cancer · AstraZeneca

Comparing Amivantamab with Cetuximab for colorectal neoplasms

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Sites in Calgary, Montreal and 2 more cities

RecruitingPHASE3

Official title: A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer

Colorectal Neoplasms · Janssen Research & Development, LLC

Comparing Hybrid Argon Plasma Coagulation (h-APC) with Snare tip soft coagulation for colorectal cancer

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One site, in Montreal

Recruiting

Official title: Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps

Colorectal Cancer · Centre hospitalier de l'Université de Montréal (CHUM)

Comparing Sotorasib with Bevacizumab-awwb for metastatic colorectal cancer

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Sites in Toronto, Brampton and 3 more cities

RecruitingPHASE3

Official title: Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

Metastatic Colorectal Cancer · Amgen

Comparing Leucovorin with Radiation for rectal cancer

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Sites in London, Montreal and 6 more cities

RecruitingPHASE3

Official title: Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Rectal Cancer · Canadian Cancer Trials Group

Testing stereotactic body radiation treatment for colorectal cancer

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One site, in Edmonton

RecruitingPHASE2

Official title: SBRT of Metastases Following Neo-adjuvant Treatment for Colorectal Cancer With Synchronous Liver Metastases

Colorectal Cancer · AHS Cancer Control Alberta

Comparing 10 approaches for metastatic colorectal cancer

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Sites in Montreal and Toronto

RecruitingPHASE1

Official title: A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

Metastatic Colorectal Cancer · Hoffmann-La Roche

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.