Heart Failure Clinical Trials

39 trials recruiting in Canada.

Heart & Circulation

Recruiting Drug Device Behavioral Older adults Healthy volunteers

35 trials · showing 30

Testing HJB647 low dose against a placebo for heart failure with reduced ejection fraction

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One site, in Montreal

RecruitingPHASE1

Official title: A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

Heart Failure With Reduced Ejection Fraction · Novartis Pharmaceuticals

Testing Finerenone with Empagliflozin for heart failure

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Sites in Toronto, Edmonton and 6 more cities

RecruitingPHASE3

Official title: A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

Heart Failure · Colorado Prevention Center

Testing Finerenone against a placebo for heart failure

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Sites in Toronto, Edmonton and 12 more cities

RecruitingPHASE3

Official title: A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

Heart Failure · Colorado Prevention Center

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Testing Elecoglipron for heart failure with preserved ejection fraction (hfpef)

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Sites in London, Markham and 14 more cities

RecruitingPHASE3

Official title: A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

Heart Failure With Preserved Ejection Fraction (HFpEF) · AstraZeneca

Testing Midodrine for heart failure with reduced ejection fraction

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One site, in Ottawa

RecruitingPHASE2

Official title: Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension

Heart Failure With Reduced Ejection Fraction · Ottawa Heart Institute Research Corporation

Testing vicadrostat with empagliflozin against a placebo for heart failure

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Sites in Montreal, Cambridge and 14 more cities

RecruitingPHASE3

Official title: A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

Heart Failure · Boehringer Ingelheim

Testing Combined Epoprostenol Sodium & Milrinone against a placebo for right heart failure

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One site, in Montreal

RecruitingPHASE2

Official title: Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation

Right Heart Failure · Montreal Heart Institute

Testing Lumacaftor against a placebo for heart failure with reduced ejection fraction

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2 sites in Toronto

RecruitingPHASE2

Official title: Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients

Heart Failure With Reduced Ejection Fraction · Qanatpharma AG

Testing Heart Failure and Mental Health for heart failure

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Sites in Ottawa, Cornwall and 3 more cities

Recruiting

Official title: Improving Care and Mental Well-Being for Adults With Heart Failure

Heart Failure · Bruyère Health Research Institute.

Testing Levocarnitine for heart failure

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One site, in London

RecruitingEARLY PHASE1

Official title: Oral Carnitine in Heart Failure Patients

Heart Failure · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Testing Maridebart cafraglutide against a placebo for heart failure with preserved ejection fraction

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Sites in Cambridge, Toronto and 16 more cities

RecruitingPHASE3

Official title: Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Heart Failure With Preserved Ejection Fraction · Amgen

Testing CDR132L against a placebo for heart failure

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Sites in Hamilton, Toronto and 6 more cities

RecruitingPHASE2

Official title: A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

Heart Failure · Novo Nordisk A/S

Testing vicadrostat with empagliflozin against a placebo for heart failure

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Sites in Québec, Brossard and 12 more cities

RecruitingPHASE3

Official title: A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

Heart Failure · Boehringer Ingelheim

Testing Omecamtiv Mecarbil (OM) against a placebo for heart failure

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Sites in Toronto, Edmonton and 11 more cities

RecruitingPHASE3

Official title: Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Heart Failure · Cytokinetics

Testing Baxdrostat and dapagliflozin for heart failure

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Sites in Toronto, Calgary and 27 more cities

RecruitingPHASE3

Official title: Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

Heart Failure · AstraZeneca

Testing Social prescribing for heart failure

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2 sites in Montreal

Recruiting

Official title: Social Prescribing to Improve Adherence and Outcomes in Women With Heart Failure

Heart Failure · McGill University Health Centre/Research Institute of the McGill University Health Centre

Testing Stopping Heart Failure Medication(s) for heart failure

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Sites in Toronto, Edmonton and 3 more cities

RecruitingPHASE4

Official title: The STOP-MED CTRCD Trial

Heart Failure · Dinesh Thavendiranathan

Testing Finerenone against a placebo for heart failure

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Sites in Edmonton, Toronto and 10 more cities

RecruitingPHASE3

Official title: A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

Heart Failure · Colorado Prevention Center

Testing NT-proBNP for heart failure

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Sites in Montreal and Vancouver

Recruiting

Official title: Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"

Heart Failure · NHS Greater Glasgow and Clyde

Testing NT-proBNP with AI echocardiogram for heart failure

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Sites in Montreal, Sherbrooke and 1 more city

Recruiting

Official title: Multidisciplinary Approach for High Risk Patients Leading to Early Diagnosis of Canadians in Heart Failure

Heart Failure · Cardiology Research UBC

Comparing Virtual HF Care with Routine HF Care for heart failure

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Sites in Hamilton, Thunder Bay and 1 more city

Recruiting

Official title: VIrtual Care To Improve Outcomes and RecoverY From Heart Failure Hospitalization

Heart Failure · Population Health Research Institute

Testing Alleviant ALV1 System against a placebo for heart failure

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Sites in Montreal and Newmarket

Recruiting

Official title: Alleviant ALLAY-HF Study

Heart Failure · Alleviant Medical, Inc.

Comparing His/LBBP with BiVP for heart failure

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Sites in Montreal, Calgary and 11 more cities

Recruiting

Official title: Left vs Left Randomized Clinical Trial

Heart Failure · Baylor College of Medicine

Comparing Lower-body Negative Pressure (-25 mmHg) with Lower-body Negative Pressure (-15 mmHg) for heart failure with preserved ejection fraction

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One site, in Kelowna

Recruiting

Official title: Exercise Lower-body Negative Pressure in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction · University of British Columbia

Testing CardioMems for chronic heart failure

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One site, in Montreal

Recruiting

Official title: Patient SELF-management With HemodynamIc Monitoring: Virtual Heart Failure Clinic and Outcomes

Chronic Heart Failure · Montreal Heart Institute

Testing Biomarker guided discharge algorithm for heart failure

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One site, in Ottawa

Recruiting

Official title: Biomarker Guided Discharge of Heart Failure Patients

Heart Failure; With Decompensation · Ottawa Heart Institute Research Corporation

Comparing 5 approaches for heart failure

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One site, in Vancouver

Recruiting

Official title: Spot Analysis of Natriuresis to Guide up- or Down-titration of Diuretic Therapy in Ambulatory Patients With Chronic Heart Failure

Heart Failure · Cardiology Research UBC

Testing Low Dose PF-07328948 against a placebo for heart failure

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Sites in Greater Sudbury, Winchester and 10 more cities

RecruitingPHASE2

Official title: A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Heart Failure · Pfizer

Testing Alleviant ALV1 System against a placebo for heart failure

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Sites in Montreal, Newmarket and 1 more city

Recruiting

Official title: Alleviant ALLAY-HFrEF Study

Heart Failure · Alleviant Medical, Inc.

Testing Personalized cardiac pacing for heart failure with preserved ejection fraction (hfpef)

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Sites in Calgary and Vancouver

Recruiting

Official title: ELEVATE-HFpEF Clinical Study

Heart Failure With Preserved Ejection Fraction (HFpEF) · Medtronic Cardiac Rhythm and Heart Failure

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.