Heart Failure Clinical Trials

39 trials recruiting in Canada.

Heart & Circulation

Recruiting Drug Device Behavioral Older adults Healthy volunteers

20 trials

Testing HJB647 low dose against a placebo for heart failure with reduced ejection fraction

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One site, in Montreal

RecruitingPHASE1

Official title: A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction

Heart Failure With Reduced Ejection Fraction · Novartis Pharmaceuticals

Testing Finerenone with Empagliflozin for heart failure

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Sites in Toronto, Edmonton and 6 more cities

RecruitingPHASE3

Official title: A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

Heart Failure · Colorado Prevention Center

Testing Finerenone against a placebo for heart failure

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Sites in Toronto, Edmonton and 12 more cities

RecruitingPHASE3

Official title: A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

Heart Failure · Colorado Prevention Center

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Testing Elecoglipron for heart failure with preserved ejection fraction (hfpef)

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Sites in London, Markham and 14 more cities

RecruitingPHASE3

Official title: A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

Heart Failure With Preserved Ejection Fraction (HFpEF) · AstraZeneca

Testing Midodrine for heart failure with reduced ejection fraction

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One site, in Ottawa

RecruitingPHASE2

Official title: Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension

Heart Failure With Reduced Ejection Fraction · Ottawa Heart Institute Research Corporation

Testing vicadrostat with empagliflozin against a placebo for heart failure

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Sites in Montreal, Cambridge and 14 more cities

RecruitingPHASE3

Official title: A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

Heart Failure · Boehringer Ingelheim

Testing Combined Epoprostenol Sodium & Milrinone against a placebo for right heart failure

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One site, in Montreal

RecruitingPHASE2

Official title: Inhaled Milrinone and Epoprostenol for the Prevention of Difficult Cardiac Pulmonary Bypass Separation

Right Heart Failure · Montreal Heart Institute

Testing Lumacaftor against a placebo for heart failure with reduced ejection fraction

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2 sites in Toronto

RecruitingPHASE2

Official title: Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients

Heart Failure With Reduced Ejection Fraction · Qanatpharma AG

Testing Levocarnitine for heart failure

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One site, in London

RecruitingEARLY PHASE1

Official title: Oral Carnitine in Heart Failure Patients

Heart Failure · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Testing Maridebart cafraglutide against a placebo for heart failure with preserved ejection fraction

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Sites in Cambridge, Toronto and 16 more cities

RecruitingPHASE3

Official title: Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Heart Failure With Preserved Ejection Fraction · Amgen

Testing CDR132L against a placebo for heart failure

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Sites in Hamilton, Toronto and 6 more cities

RecruitingPHASE2

Official title: A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

Heart Failure · Novo Nordisk A/S

Testing vicadrostat with empagliflozin against a placebo for heart failure

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Sites in Québec, Brossard and 12 more cities

RecruitingPHASE3

Official title: A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

Heart Failure · Boehringer Ingelheim

Testing Omecamtiv Mecarbil (OM) against a placebo for heart failure

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Sites in Toronto, Edmonton and 11 more cities

RecruitingPHASE3

Official title: Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

Heart Failure · Cytokinetics

Testing Baxdrostat and dapagliflozin for heart failure

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Sites in Toronto, Calgary and 27 more cities

RecruitingPHASE3

Official title: Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

Heart Failure · AstraZeneca

Testing Finerenone against a placebo for heart failure

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Sites in Edmonton, Toronto and 10 more cities

RecruitingPHASE3

Official title: A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

Heart Failure · Colorado Prevention Center

Testing Vericiguat against a placebo for heart failure

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Sites in Edmonton, Sherbrooke and 1 more city

RecruitingPHASE2

Official title: Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

Heart Failure · Merck Sharp & Dohme LLC

Testing Low Dose PF-07328948 against a placebo for heart failure

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Sites in Greater Sudbury, Winchester and 10 more cities

RecruitingPHASE2

Official title: A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

Heart Failure · Pfizer

Testing Vericiguat for heart failure

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Sites in Calgary, Edmonton and 2 more cities

RecruitingPHASE2

Official title: COgnitioN With VERiciGuat Evaluation in Heart Failure

Heart Failure · University of Alberta

Comparing 3 approaches for heart failure and impaired kidney function

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Sites in Montreal, Cambridge and 21 more cities

RecruitingPHASE3

Official title: Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

Heart Failure and Impaired Kidney Function · AstraZeneca

Testing Colchicine with Thiamine Mononitrate against a placebo for heart failure

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One site, in Hamilton

RecruitingPHASE3

Official title: COLchicine and Thiamine in Heart Failure Due to Ischemic Heart Disease

Heart Failure · Hamilton Health Sciences Corporation

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.