Major Depressive Disorder Clinical Trials

65 trials recruiting in Canada.

Mental Health

Recruiting Drug Device Behavioral Older adults Healthy volunteers

20 trials

Comparing Ketamine with ECT for treatment resistant depression

Explore this study →

One site, in Saskatoon

Official title: ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression

Treatment Resistant Depression · University of Saskatchewan

Testing Escitalopram against a placebo for major depressive disorder

Explore this study →

Sites in Toronto, Calgary and 7 more cities

RecruitingPHASE4

Official title: Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)

Major Depressive Disorder · Nova Scotia Health Authority

Testing Apo-levocarb for major depressive disorder

Explore this study →

One site, in Vancouver

RecruitingPHASE2

Official title: Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial

Major Depressive Disorder · University of British Columbia

Get matched to the best-fit trials

Answer a few questions and we'll find the closest matches for major depressive disorder.

Testing NBI-1065845 against a placebo for major depressive disorder

Explore this study →

Sites in Toronto and Verdun

RecruitingPHASE3

Official title: NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder · Neurocrine Biosciences

Comparing 3 approaches for major depressive disorder

Explore this study →

Sites in Calgary, Kingston and 3 more cities

RecruitingPHASE3

Official title: A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder · Neurocrine Biosciences

Testing Psilocybin for treatment-resistant depression

Explore this study →

2 sites in Toronto

RecruitingPHASE2

Official title: Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression

Treatment-Resistant Depression · Centre for Addiction and Mental Health

Testing Dextromethorphan-Bupropion for major depressive disorder (MDD)

Explore this study →

One site, in Toronto

RecruitingPHASE2

Official title: Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder

Major Depressive Disorder (MDD) · Roger McIntyre

Comparing Cognitive Behavioral Therapy with Pharmacotherapy for major depressive disorder

Explore this study →

One site, in Halifax

RecruitingPHASE4

Official title: Personalized Indications for CBT and Antidepressants in Treating Depression

Major Depressive Disorder · Nova Scotia Health Authority

Testing Brexpiprazole for bipolar depression

Explore this study →

Sites in Montreal and Hamilton

RecruitingPHASE3

Official title: Brexpiprazole Treatment for Bipolar I Depression

Bipolar Depression · Douglas Mental Health University Institute

Comparing Cognitive-Behavioural Therapy with Antidepressant medication for depression

Explore this study →

Sites in Halifax and Montreal

RecruitingPHASE2

Official title: Treatment Interrupts Depression Early

Depression · Nova Scotia Health Authority

Comparing Ketamine hydrochloride with Midazolam Hydrochloride for major depressive disorder

Explore this study →

One site, in Toronto

RecruitingPHASE2

Official title: i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial

Major Depressive Disorder · University Health Network, Toronto

Testing Psilocybin for treatment resistant depression

Explore this study →

One site, in Toronto

RecruitingPHASE2

Official title: Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

Treatment Resistant Depression · Centre for Addiction and Mental Health

Testing VLS-01-203 BU against a placebo for treatment resistant depression

Explore this study →

Sites in Kingston and Surrey

RecruitingPHASE2

Official title: A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

Treatment Resistant Depression · atai Therapeutics, Inc.

Testing Acceptance and Commitment Therapy with Ketamine for depression - major depressive disorder

Explore this study →

One site, in Montreal

Recruiting

Official title: ACT_for Alcohol Use Disorder and Depression

Depression - Major Depressive Disorder · Centre hospitalier de l'Université de Montréal (CHUM)

Testing Brenipatide against a placebo for major depressive disorder

Explore this study →

Sites in Québec, Calgary and 10 more cities

RecruitingPHASE3

Official title: A Study of Brenipatide in Adult Participants With Major Depressive Disorder

Depressive Disorder, Major · Eli Lilly and Company

Comparing Psilocybin with Microcrystalline cellulose for depressive disorder

Explore this study →

One site, in Toronto

RecruitingPHASE2

Official title: A Randomized Neuroimaging Trial of Psilocybin in Depression

Depressive Disorder · Sunnybrook Health Sciences Centre

Comparing Oculus VR headset with Ketamine for treatment resistant depression

Explore this study →

One site, in Toronto

RecruitingPHASE3

Official title: InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression

Treatment Resistant Depression · Sunnybrook Health Sciences Centre

Testing NBI-1065845 for major depressive disorder

Explore this study →

One site, in Toronto

RecruitingPHASE3

Official title: Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder · Neurocrine Biosciences

Comparing Risperidone with Psilocybin for treatment resistant depression

Explore this study →

One site, in Toronto

RecruitingPHASE2

Official title: Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

Treatment Resistant Depression · Centre for Addiction and Mental Health

Testing Seltorexant against a placebo for major depressive disorder

Explore this study →

One site, in North Vancouver

RecruitingPHASE3

Official title: A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

Depressive Disorder, Major · Janssen Research & Development, LLC

Looking for the closest fit?

Get matched →

Get notified when a matching trial opens

We'll watch for Major Depressive Disorder trials near you.

← Back to all conditions

Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.