Prostate Cancer Clinical Trials

Official title: A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

Advanced Prostate Cancer · Genentech, Inc.

Comparing Metastasis directed radiotherapy with no MDRT for prostate cancer metastatic

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One site, in Montreal

Official title: Radiotherapy to Consolidate Systemic Response in Metastatic Prostate Cancer (ANCHOR-Prostate)

Prostate Cancer Metastatic · Centre hospitalier de l'Université de Montréal (CHUM)

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Comparing Actinium (225Ac) zadavotide guraxetan with Cabazitaxel for metastatic castration-resistant prostate cancer

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Sites in Montreal, Toronto and 3 more cities

Official title: AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

Metastatic Castration-resistant Prostate Cancer · AstraZeneca

Testing radiotherapy for prostate cancer

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One site, in Lethbridge

Official title: Radiation Treatment of the Prostate That is Specially Adjusted for Each Person

Prostate Cancer · AHS Cancer Control Alberta

Testing PET Tracer for mcrpc (metastatic castration-resistant prostate cancer)

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One site, in Québec

Official title: Four-Timepoint Multi-tracer PET Imaging to Characterize Metastatic prOstate Cancer Heterogeneity

mCRPC (Metastatic Castration-resistant Prostate Cancer) · Frederic Pouliot

Comparing 4 approaches for prostate cancer

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Sites in Québec and Toronto

Official title: A Study to Learn How Safe AZD6621 is, How Well it Works, and How it Moves Throughout the Body Over Time, in Adult Male Participants With Metastatic Prostate Cancer

Prostate Cancer · AstraZeneca

Testing Post radical prostatectomy nerve for prostate cancer

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One site, in Montreal

Official title: A Study Looking at a New Nerve Surgery to Help Men Regain Erections After Prostate Cancer Surgery

Prostate Cancer · Sir Mortimer B. Davis - Jewish General Hospital

Comparing Mevrometostat with Enzalutamide for metastatic castration sensitive prostate cancer (mcspc)

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Sites in Montreal, Calgary and 7 more cities

Official title: This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Metastatic Castration Sensitive Prostate Cancer (mCSPC) · Pfizer

Testing 177Lu-PSMA-617 for metastatic castrate resistant prostate cancer (mcrpc)

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One site, in Québec

Official title: Personalized vs. Fixed-Activity 177Lu-PSMA-617 Radiopharmaceutical Therapy (PRODIGY-2)

Metastatic Castrate Resistant Prostate Cancer (mCRPC) · Jean-Mathieu Beauregard

Testing SBRT for localized prostate cancer

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One site, in Toronto

Official title: Is Adaptive SBRT for Prostate vs Image-guided Radiotherapy a True Evolution (ASPIRE)

Localized Prostate Cancer · University Health Network, Toronto

Comparing ELIGARD with Recurrence-directed therapy for prostate adenocarcinoma

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Sites in Hamilton, Montreal and 1 more city

Official title: Study of Recurrence-directed Therapy (RDT) With or Without Androgen-Deprivation Therapy (ADT) In Patients With Radio-recurrent Oligo-metastatic Hormone/Castrate Sensitive Prostate Cancer (romCSPC)

Prostate Adenocarcinoma · Ontario Clinical Oncology Group (OCOG)

Testing Prostate radical radiotherapy for prostate cancer

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One site, in Toronto

Official title: Dose dE-eScalaTion IN prostATe radIOtherapy usiNg an MR-Linac in 2 Fractions

Prostate Cancer · Royal Marsden NHS Foundation Trust

Comparing Abiraterone with Docetaxel for prostate cancer (adenocarcinoma)

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Sites in Montreal, Toronto and 15 more cities

Official title: Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

Prostate Cancer (Adenocarcinoma) · Canadian Cancer Trials Group

Testing Intraoperative Somatic-Autonomic Nerve for prostate cancer

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2 sites in Montreal

Official title: Nerve Grafting Technique to Preserve Erectile Function in Patients Undergoing Robotic Assisted Radical Prostatectomy

Prostate Cancer · Sir Mortimer B. Davis - Jewish General Hospital

Comparing 177Lu-TLX591 with Enzalutamide for metastatic castration-resistant prostate cancer

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Sites in Burnaby and Toronto

Official title: The Study of 177Lu-TLX591 Plus SOC Versus SOC Alone in Patients With mCRPC (ProstACT Global)

Metastatic Castration-resistant Prostate Cancer · Telix Pharmaceuticals (Innovations) Pty Limited

Testing Irreversible Electroporation (NanoKnife) for prostate cancer

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One site, in Toronto

Official title: A Pan-Canadian, Investigator Initiated Clinical Trial With Focal IRE Directed to Intermediate-Risk Prostate Cancer

Prostate Cancer · University Health Network, Toronto

Testing Radiotherapy for post-operative prostate cancer

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Sites in London and Toronto

Official title: Comparing Moderately Ultra Hypofractionated Radiation Treatments for Prostate Cancer

Post-Operative Prostate Cancer · University Health Network, Toronto

Testing Ga 68 PSMA-11 PET with 18F-DCFPyL PET for advanced prostate cancer

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One site, in Toronto

Official title: Dual PSMA and FDG PET Imaging for Patients With Advanced Prostate Cancer

Advanced Prostate Cancer · University Health Network, Toronto

Testing MR Linac delivered Radiotherapy for prostate cancer

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One site, in Toronto

Official title: Pilot Study of Dose Escalation in Prostate Radiotherapy Using the MR-Linac (DESTINATION-MRL)

Prostate Cancer · Sunnybrook Health Sciences Centre

Comparing Opevesostat with Abiraterone acetate for metastatic castration-resistant prostate cancer (mcrpc)

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Sites in Abbotsford British Columbia, Edmonton and 5 more cities

Official title: A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

Metastatic Castration-resistant Prostate Cancer (mCRPC) · Merck Sharp & Dohme LLC

Comparing Opevesostat with Abiraterone acetate for prostate cancer metastatic

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Sites in Toronto, Edmonton and 5 more cities

Official title: Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

Prostate Cancer Metastatic · Merck Sharp & Dohme LLC

Testing BMS-986460 for metastatic castration-resistant prostate cancer

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Sites in Montreal and Toronto

Official title: A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

Metastatic Castration-resistant Prostate Cancer · Bristol-Myers Squibb

Testing PSMA-1007 Positron Emission Tomography for prostate cancer

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Sites in Edmonton, Calgary and 1 more city

Official title: PSMA-Guided Ablation of the Prostate

Prostate Cancer · University of Alberta

Testing AAA617 with piflufolastat for oligometastatic prostate cancer (OMPC)

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Sites in Montreal, Calgary and 5 more cities

Official title: An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

Oligometastatic Prostate Cancer (OMPC) · Novartis Pharmaceuticals

Testing AAA617 for prostate cancer

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One site, in Montreal

RecruitingPHASE4

Official title: Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

Prostate Cancer · Novartis Pharmaceuticals

Testing Apple Cider Vinegar for prostate cancer

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One site, in London

RecruitingEARLY PHASE1

Official title: Akkermansia Muciniphilia and Metabolic Side Effects of ADT

Prostate Cancer · Western University

Testing Radiotherapy for prostate metastases

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One site, in Toronto

Official title: Consolidative Prostate Radiotherapy in Metastatic Prostate Cancer

Prostate Metastases · University Health Network, Toronto

Testing Stereotactic Ablative Body Radiation for prostate cancer

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One site, in Toronto

Official title: Improving Sexual Quality of Life - Randomized Trial of Two vs Five MRI Guided SABR Treatments for Prostate Cancer

Prostate Cancer · Sunnybrook Health Sciences Centre

Testing SpaceOAR for prostate cancer

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One site, in Toronto