Rheumatoid Arthritis Clinical Trials

Official title: Adapting Rehabilitation Delivery for Maximum Impact at Home-2 (ReDI-2)

Knee Osteoarthritis · University of Alberta

Testing Tulisokibart against a placebo for radiographic axial spondyloarthritis

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Sites in Québec, Toronto and 1 more city

Official title: A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Radiographic Axial Spondyloarthritis · Merck Sharp & Dohme LLC

Comparing 3 approaches for psoriatic arthritis

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Sites in Niagara Falls, Québec and 1 more city

Official title: A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

Psoriatic Arthritis · Takeda

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Testing Eloralintide against a placebo for osteoarthritis

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Sites in Québec, Toronto and 3 more cities

Official title: Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Osteoarthritis · Eli Lilly and Company

Testing Orforglipron against a placebo for osteoarthritis

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Sites in Québec, Brampton and 4 more cities

Official title: A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Osteoarthritis · Eli Lilly and Company

Testing Tulisokibart against a placebo for psoriatic arthritis

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Sites in Rimouski and Trois-Rivières

Official title: Study to Evaluate Tulisokibart in Adults With Psoriatic Arthritis (MK-7240-015)

Psoriatic Arthritis · Merck Sharp & Dohme LLC

Testing AZD1163 against a placebo for rheumatoid arthritis

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Sites in Trois-Rivières and Windsor

Official title: A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis

Rheumatoid Arthritis · AstraZeneca

Testing Glucocorticoid (GC) for rheumatoid arthritis (RA)

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5 sites in Toronto

Official title: Oral Versus Intramuscular Steroid Use to Control Rheumatoid Arthritis Flares

Rheumatoid Arthritis (RA) · Sunnybrook Health Sciences Centre

Testing Lutikizumab against a placebo for rheumatoid arthritis

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Sites in Calgary, Saskatoon and 1 more city

Official title: A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

Rheumatoid Arthritis · AbbVie

Comparing 3 approaches for psoriatic arthritis

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Sites in Saskatoon and Trois-Rivières

Official title: Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis

Psoriatic Arthritis · AbbVie

Testing Icotrokinra against a placebo for psoriatic arthritis

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Sites in Montreal, Orillia and 5 more cities

Official title: A Study to Evaluate the Efficacy and Safety of Icotrokinra (JNJ-77242113) in Biologic-experienced and Biologic-naive Participants With Active Psoriatic Arthritis

Arthritis, Psoriatic · Janssen Research & Development, LLC

Testing Sonelokimab against a placebo for psoriatic arthritis

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Sites in Calgary, Toronto and 3 more cities

Official title: Evaluation of Sonelokimab in Patients With Active Psoriatic Arthritis and Anti-TNFα Inadequate Response

Arthritis, Psoriatic · MoonLake Immunotherapeutics AG

Testing Upadacitinib against a placebo for psoriatic arthritis

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Sites in Ottawa and Québec

Official title: A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis

Psoriatic Arthritis · CARE ARTHRITIS LTD.

Comparing 4 approaches for rheumatoid arthritis

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One site, in Montreal

Official title: Stand UP to Rheumatoid Arthritis (SUPRA)

Rheumatoid Arthritis · Marie Hudson, MD

Comparing targeted synthetic DMARD class with non-TNFi-biologic class for rheumatoid arthritis

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One site, in Toronto

Official title: RA-PRO PRAGMATIC TRIAL

Rheumatoid Arthritis · University of Alabama at Birmingham

Testing Hydroxychloroquine against a placebo for arthritis

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One site, in Edmonton

Official title: Immune-Mediated Pathophysiology And Clinical Triage Program

Arthritis · AHS Cancer Control Alberta

Comparing Etanercept with tofacitinib for rheumatoid arthritis

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One site, in London

Official title: Advanced Therapeutics in Rheumatoid Arthritis (RA)

Rheumatoid Arthritis · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Comparing XPERIENCE Advanced Surgical Irrigation with Dilute Betadine for hip osteoarthritis

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Sites in Montreal, Toronto and 4 more cities

Official title: Evaluating XPERIENCE™ Advanced Surgical Irrigation

Hip Osteoarthritis · Ottawa Hospital Research Institute

Testing bariatric surgery followed by total for knee osteoarthritis

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One site, in Halifax

Official title: Optimal Management of Extreme Obesity and Severe Knee Osteoarthritis Feasibility Trial

Knee Osteoarthritis · Nova Scotia Health Authority

Testing Primary Care Rheumatology Family for rheumatoid arthritis

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One site, in Waterloo

Official title: Comorbidity Management in Rheumatic Disease.

Rheumatoid Arthritis · Western University, Canada

Testing Duloxetine against a placebo for knee osteoarthritis

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2 sites in Toronto

Official title: Effect of peRiopErative duLoxetIne Administration on Opioid Consumption Following Total kneE Arthroplasty (RELIFE)

Knee Osteoarthritis · Sunnybrook Health Sciences Centre

Testing Choose to Move Replacement Ready for osteoarthritis (OA)

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One site, in Vancouver

Official title: Evaluation of Choose to Move Replacement Ready (CTM-RR)

Osteoarthritis (OA) · University of British Columbia

Testing Choose to Move Replacement Ready for osteoarthritis

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One site, in Vancouver

Official title: Feasibility of Choose to Move Replacement Ready

Osteoarthritis · University of British Columbia

Testing Yoga against a placebo for knee osteoarthritis

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Sites in Hamilton, London and 1 more city

Official title: Transcranial Direct Current Stimulation and Yoga for Knee Osteoarthritis

Knee Osteoarthritis · McMaster University

Testing FitJoints Multi-modal Intervention for hip osteoarthritis

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Sites in Hamilton, Calgary and 1 more city

Official title: FitJoints: Getting Fit for Hip and Knee Replacement

Hip Osteoarthritis · McMaster University

Comparing Eccentric Reaming with Posterior Glenoid Bone Grafting for shoulder osteoarthritis

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One site, in Ottawa

Official title: TSA Techniques in Glenohumeral OA

Osteoarthritis, Shoulder · Ottawa Hospital Research Institute

Testing Bone Marrow Aspirate (BMA): Minimally against a placebo for knee osteoarthritis

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2 sites in Toronto

Official title: Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA

Osteoarthritis, Knee · University Health Network, Toronto

Comparing RTSA with subscapularis repair with RTSA without subscapularis repair for arthritis shoulder

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One site, in Winnipeg

Official title: Comparison of Lateralized RTSA With and Without Subscapularis Repair

Arthritis Shoulder · Panam Clinic

Testing Partial synovectomy for knee osteoarthritis

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One site, in London

Official title: The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty

Osteoarthritis, Knee · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Comparing Total Shoulder Arthroplasty with Reverse Shoulder Arthroplasty for osteoarthritis of the shoulder

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Sites in Edmonton, Kingston and 2 more cities