Brain Cancer Clinical Trials

Trials for someone you care about with brain cancer.

Cancer

Recruiting Drug Device Behavioral Older adults Healthy volunteers

20 trials

Comparing Etoposide with Tamoxifen for glioblastoma multiforme

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One site, in Edmonton

RecruitingPHASE2

Official title: Tamoxifen Versus Etoposide After First Recurrence in GBM Patients

Glioblastoma Multiforme · AHS Cancer Control Alberta

Testing Belzutifan for pheochromocytoma/paraganglioma

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Sites in Calgary and Toronto

RecruitingPHASE2

Official title: Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Pheochromocytoma/Paraganglioma · Merck Sharp & Dohme LLC

Comparing Blood Brain Barrier Opening with Pembrolizumab for brain tumor

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One site, in Toronto

RecruitingPHASE3

Official title: Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets

Brain Tumor · InSightec

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Comparing IA Carboplatin + IA Caelyx with IA Carboplatin + IA Etoposide Phosphate for glioblastoma multiforme

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One site, in Sherbrooke

RecruitingPHASE2

Official title: Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma

Glioblastoma Multiforme · Université de Sherbrooke

Testing TRANEXAMIC ACID against a placebo for brain tumor

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One site, in Halifax

RecruitingPHASE3

Official title: The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies

Brain Tumor · Stephen Lownie

Comparing Nivolumab with Radiation for high grade glioma

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One site, in Toronto

Recruiting

Official title: A Pilot Study Investigating Upfront Adaptive Immunotherapy Approach in Children, Adolescent and Young Adult (CAYA) Patients With Replication-Repair Deficient (RRD) High-Grade Gliomas (HGG)

High Grade Glioma · Daniel Morgenstern

Testing ACT001 for diffuse intrinsic pontine gliomas (DIPG)

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Sites in Montreal and Toronto

RecruitingPHASE2

Official title: ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas

Diffuse Intrinsic Pontine Gliomas (DIPG) · Nationwide Children's Hospital

Testing Daily TMZ for glioblastoma

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One site, in Toronto

RecruitingPHASE2

Official title: Daily Temozolomide for Elderly Patients With Unmethylated MGMT- Promoter Newly Diagnosed GliOblatoma

Glioblastoma · Sunnybrook Health Sciences Centre

Testing Optune® device with Temozolomide against a placebo for glioblastoma

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Sites in Montreal, Edmonton and 4 more cities

RecruitingPHASE3

Official title: EF-41/KEYNOTE D58: Phase 3 Study of Optune Concomitant With Temozolomide Plus Pembrolizumab in Newly Diagnosed Glioblastoma

Glioblastoma · NovoCure GmbH

Testing Tovorafenib with Vinblastine for low-grade glioma

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One site, in Toronto

RecruitingEARLY PHASE1

Official title: Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas

Low-grade Glioma · Daniel Morgenstern

Testing Afatinib with Dasatinib for glioblastoma

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One site, in Calgary

RecruitingEARLY PHASE1

Official title: Pilot Trial for Treatment of Recurrent Glioblastoma

Glioblastoma · AHS Cancer Control Alberta

Comparing 3 approaches for low-grade glioma

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Sites in Montreal and Québec

RecruitingPHASE2

Official title: A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

Low-grade Glioma · Day One Biopharmaceuticals, Inc.

Comparing 4 approaches for high grade glioma

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Sites in Montreal and Toronto

RecruitingEARLY PHASE1

Official title: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

High Grade Glioma · Nationwide Children's Hospital

Comparing 3 approaches for high grade glioma

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Sites in Montreal and Toronto

RecruitingPHASE2

Official title: Study of Olutasidenib and Temozolomide in HGG

High Grade Glioma · Rigel Pharmaceuticals

Comparing 5 approaches for high grade glioma

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Sites in Montreal and Toronto

RecruitingPHASE2

Official title: Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

High Grade Glioma · Nationwide Children's Hospital

Testing Biopsy Procedure with Magnetic Resonance Imaging for malignant glioma

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Sites in Montreal, Edmonton and 8 more cities

RecruitingPHASE1

Official title: A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

Malignant Glioma · National Cancer Institute (NCI)

Comparing 6 approaches for glioblastoma multiforme

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One site, in Sherbrooke

RecruitingPHASE1

Official title: IA Carboplatin + Radiotherapy in Relapsing GBM

Glioblastoma Multiforme · Université de Sherbrooke

Comparing 17 approaches for glioblastoma

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Sites in Toronto, Montreal and 1 more city

RecruitingPHASE2

Official title: A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Glioblastoma · Global Coalition for Adaptive Research

Testing Mirdametinib for pediatric low-grade glioma

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Sites in Calgary, Edmonton and 7 more cities

RecruitingPHASE1

Official title: Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK

Pediatric Low-grade Glioma · St. Justine's Hospital

Comparing Larotrectinib with Larotrectinib surgical for high grade glioma

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Sites in Montreal and Toronto

RecruitingEARLY PHASE1

Official title: A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

High Grade Glioma · Nationwide Children's Hospital

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.