Breast Cancer Clinical Trials

Trials for someone you care about with breast cancer.

Cancer

Recruiting Drug Device Behavioral Older adults Healthy volunteers

78 trials · showing 30

Testing Ribociclib with Letrozole for early breast cancer

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Sites in Montreal, Toronto and 6 more cities

RecruitingPHASE3

Official title: Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Early Breast Cancer · Novartis Pharmaceuticals

Testing Inavolisib with Ribociclib against a placebo for breast cancer

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Sites in Chicoutimi, Montreal and 2 more cities

RecruitingPHASE2

Official title: A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer

Breast Cancer · Hoffmann-La Roche

Testing LY4064809 against a placebo for breast neoplasms

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Sites in Hamilton, Québec and 2 more cities

RecruitingPHASE3

Official title: A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Breast Neoplasms · Eli Lilly and Company

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Comparing 4 approaches for breast cancer

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One site, in Toronto

RecruitingPHASE1

Official title: A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

Breast Cancer · Genentech, Inc.

Comparing 7 approaches for breast cancer

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Sites in Toronto and Vancouver

RecruitingPHASE1

Official title: A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors

Breast Cancer · Eli Lilly and Company

Comparing 4 approaches for metastatic breast cancer

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Sites in Kitchener, Ottawa and 1 more city

RecruitingPHASE4

Official title: Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic Breast and Prostate Cancers

Metastatic Breast Cancer · Ottawa Hospital Research Institute

Testing Radiation with Pembrolizumab (KEYTRUDA®) for breast cancer

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2 sites in London

RecruitingPHASE2

Official title: Neoadjuvant, SBRT With Intratumoural Pembrolizumab Followed by Neoadjuvant Chemotherapy in Breast Cancer

Breast Cancer · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Comparing Axillary lymph node dissection with Axillary radiotherapy for breast cancer

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One site, in Montreal

Recruiting

Official title: Axillary Radiotherapy or Axillary Lymph Node Dissection in Patients With Clinically Node- Positive Breast Cancer Undergoing Upfront Tailored Axillary Surgery

Breast Cancer · University Hospital, Basel, Switzerland

Comparing 5 approaches for breast neoplasms

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Sites in Toronto, Hamilton and 1 more city

RecruitingPHASE1

Official title: A Study of LY4257496 in Participants With Cancer (OMNIRAY)

Breast Neoplasms · Eli Lilly and Company

Comparing Palazestrant with Letrozole for breast cancer

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One site, in Toronto

RecruitingPHASE3

Official title: Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

Breast Cancer · Olema Pharmaceuticals, Inc.

Comparing 7 approaches for breast cancer

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Sites in Montreal, Toronto and 1 more city

RecruitingPHASE2

Official title: A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Breast Cancer · Hoffmann-La Roche

Comparing 3 approaches for breast cancer

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Sites in Calgary, Kitchener and 1 more city

RecruitingPHASE1

Official title: A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer

Breast Cancer · Pfizer

Comparing Multiple Fraction PBI with Single Fraction PBI for breast cancer early stage breast cancer (stage 1-3)

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One site, in Prince George

Recruiting

Official title: Single vs Hypofractionated Irradiation For Timely Access to Partial Breast Radiotherapy

Breast Cancer Early Stage Breast Cancer (Stage 1-3) · British Columbia Cancer Agency

Comparing 3 approaches for breast neoplasms

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Sites in Montreal, Kingston and 1 more city

RecruitingPHASE1

Official title: Study of Patritumab Deruxtecan With Other Anticancer Agents in Participants With HER2 Positive Breast Cancer That Has Spread and Cannot Be Surgically Removed (MK-1022-009)

Breast Neoplasms · Merck Sharp & Dohme LLC

Comparing Zanidatamab with Trastuzumab for metastatic HER2-positive breast cancer

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Sites in Montreal, Ottawa and 3 more cities

RecruitingPHASE3

Official title: A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Metastatic HER2-positive Breast Cancer · Jazz Pharmaceuticals

Testing Definity with Sonalleve Focused Ultrasound Device for breast cancer

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One site, in Toronto

RecruitingPHASE2

Official title: Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer

Breast Cancer · Sunnybrook Health Sciences Centre

Comparing Ovarian Function Suppression + with Adjuvant Chemotherapy + Ovarian for breast cancer

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Sites in Montreal, Barrie and 9 more cities

RecruitingPHASE3

Official title: Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Breast Cancer · NRG Oncology

Comparing Lasofoxifene in combination with with Fulvestrant in combination with for metastatic breast cancer

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Sites in Montreal, Ottawa and 2 more cities

RecruitingPHASE3

Official title: Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Metastatic Breast Cancer · LeonaBio

Testing Dual-Energy Contrast-Enhanced Spectral for breast cancer

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One site, in London

Recruiting

Official title: Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts

Breast Cancer · American College of Radiology

Comparing Radiation and Endocrine Therapy with Endocrine Therapy (Tamoxifen, for stage i breast cancer

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Sites in Kingston, Montreal and 5 more cities

RecruitingPHASE3

Official title: De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Stage I Breast Cancer · NRG Oncology

Testing Celecoxib (Celebrex) against a placebo for triple-negative breast cancer

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One site, in Sherbrooke

RecruitingPHASE2

Official title: Triple Negative Breast Cancer and Celecoxib. Pilot Study

Triple-Negative Breast Cancer · Université de Sherbrooke

Comparing 3 approaches for triple negative breast neoplasms

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Sites in Montreal, Toronto and 5 more cities

RecruitingPHASE3

Official title: A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

Triple Negative Breast Neoplasms · Merck Sharp & Dohme LLC

Comparing STAR0602 with Sacituzumab Govitecan (SG) for triple negative locally advanced non-resectable breast

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Sites in Toronto and Vancouver

RecruitingPHASE1

Official title: A Study of Invikafusp Alfa (STAR0602), a Selective T Cell Receptor (TCR)-Targeting, Bifunctional Antibody-fusion Molecule, in Combination With Sacituzumab Govitecan in Participants With Advanced Solid Tumors

Triple Negative Locally Advanced Non-resectable Breast Cancer · Marengo Therapeutics, Inc.

Comparing 8 approaches for locally advanced breast cancer

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Sites in Chicoutimi, Toronto and 1 more city

RecruitingPHASE1

Official title: A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer

Locally Advanced Breast Cancer · BioNTech SE

Testing Cognitive-behavioral group therapy for breast cancer susceptibility gene (BRCA1) mutation

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One site, in Québec

Recruiting

Official title: Cognitive Behavioral Therapy for Fear of Cancer Recurrence in Women With BRCA1/2 Gene

Breast Cancer Susceptibility Gene (BRCA1) Mutation · CHU de Quebec-Universite Laval

Testing Inavolisib with CDK4/6i against a placebo for breast cancer

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Sites in Montreal, Toronto and 7 more cities

RecruitingPHASE3

Official title: A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

Breast Cancer · Hoffmann-La Roche

Testing Sacituzumab Govitecan for breast cancer

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One site, in Vancouver

RecruitingPHASE2

Official title: Genomic and Transcriptomic Predictors of Sequential SG Sensitivity After T-DXd in ER+/HER2-Low Metastatic Breast Cancer

Breast Cancer · British Columbia Cancer Agency

Testing MR-Guided Focused Ultrasound Technology with Definity Suspension for for breast cancer

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One site, in Toronto

RecruitingPHASE1

Official title: MRI-Guided Ultrasound Stimulated Microbubbles Radiation Treatment for Patients with Chest-Wall and Locally Advanced Breast Cancer

Breast Cancer · Sunnybrook Health Sciences Centre

Comparing 5 approaches for breast cancer

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One site, in Toronto

Recruiting

Official title: Alternative Physical Activity Strategies for Breast Cancer Survivors

Breast Cancer · University of Toronto

Comparing Elacestrant with Anastrozole for breast cancer

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Sites in Toronto, Barrie and 7 more cities

RecruitingPHASE3

Official title: A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

Breast Cancer · Stemline Therapeutics, Inc.

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.