Lung Cancer Clinical Trials

Official title: Non-ablative Oligofractionated Radiation Therapy Before Surgical Transplantation As Radiovaccination

Transplant-Related Lung Cancer · Marc de Perrot

Comparing Sevabertinib with Pembrolizumab for HER2 mutation advanced non-small cell lung cancer

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Sites in Brampton, Montreal and 2 more cities

Official title: A Study to Learn More About How Well Sevabertinib Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Advanced Non-small Cell Lung Cancer, HER2 Mutation · Bayer

Comparing Telisotuzumab Vedotin with Docetaxel for non small cell lung cancer

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Sites in Brampton, Edmonton and 3 more cities

Official title: A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Non Small Cell Lung Cancer · AbbVie

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Testing 225Ac-ETN029 with 111In-ETN029 for small cell lung carcinoma

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One site, in Montreal

Official title: Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

Small Cell Lung Carcinoma · Novartis Pharmaceuticals

Comparing Calderasib with Pemetrexed for non-small cell lung cancer

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One site, in Edmonton

Official title: A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC

Comparing 5 approaches for locally advanced or metastatic KRAS G12C-mutated non-small

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Sites in Montreal and Sherbrooke

Official title: Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer · Novartis Pharmaceuticals

Testing Belimumab against a placebo for interstitial lung diseases

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Sites in Montreal and Trois-Rivières

Official title: A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue Disease

Lung Diseases, Interstitial · GlaxoSmithKline

Comparing 4 approaches for non-small cell lung cancer

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Sites in Montreal, Ottawa and 1 more city

Official title: A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Non-Small Cell Lung Cancer · Hoffmann-La Roche

Testing LY3537982 against a placebo for non-small-cell lung carcinoma

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Sites in Abbotsford British Columbia, Chicoutimi and 1 more city

Official title: A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung · Eli Lilly and Company

Comparing Calderasib with Pembrolizumab for non-small cell lung cancer

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Sites in Halifax, Hamilton and 4 more cities

Official title: A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC

Comparing Divarasib with Pemetrexed for non-small cell lung cancer

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Sites in Barrie, Brampton and 7 more cities

Official title: A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer · Hoffmann-La Roche

Comparing Pumitamig with Durvalumab for non-small cell lung cancer (NSCLC)

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Sites in Montreal, Ottawa and 1 more city

Official title: A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

Non-small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb

Comparing Pumitamig with Pembrolizumab for non-small cell lung cancer (NSCLC)

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Sites in Halifax, Oshawa and 3 more cities

Official title: A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

Non-Small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb

Testing Tozorakimab against a placebo for viral lung infection and acute respiratory failure

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Sites in Montreal, Winnipeg and 8 more cities

Official title: Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

Viral Lung Infection and Acute Respiratory Failure · AstraZeneca

Testing Mycophenolate Mofetil against a placebo for systemic sclerosis with lung involvement

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Sites in Montreal and Québec

Official title: Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease

Systemic Sclerosis With Lung Involvement · Centre hospitalier de l'Université de Montréal (CHUM)

Comparing Exertional Oxygen with Education and Support for fibrotic interstitial lung disease

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One site, in Edmonton

Official title: Ambulatory Oxygen Therapy for Individuals With Mild-to-moderate Interstitial Lung Disease

Fibrotic Interstitial Lung Disease · University of Alberta

Comparing 3 approaches for fibrosing interstitial lung disease

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Sites in Calgary and Toronto

Official title: A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)

Fibrosing Interstitial Lung Disease · Boehringer Ingelheim

Testing Chest CT Scan for lung cancer

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One site, in Vancouver

Official title: Improving Detection of Early Lung Cancer in a Diverse Population (IDEAL) Study

Lung Cancer · British Columbia Cancer Agency

Comparing 3 approaches for lung cancer

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One site, in Saskatoon

Official title: Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)

Lung Cancer · University of Saskatchewan

Testing Oxaliplatin for lung metastases

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One site, in Toronto

Official title: In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung

Lung Metastases · University Health Network, Toronto

Testing Prehabilitation for neoplasm of lung

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One site, in Halifax

Official title: Prehab for Lung and Esophageal Cancer

Neoplasm of Lung · Nova Scotia Health Authority

Testing Vitamin D3 Drops with Coriolus Versicolor for lung cancer

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Sites in Ottawa and Toronto

Official title: The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III

Lung Cancer · Ottawa Hospital Research Institute

Testing Stereotactic Radiation for non-small cell lung cancer

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One site, in Toronto

Official title: Stereotactic Radiotherapy (SBRT) of Lung Metastasis

Non-small Cell Lung Cancer · University Health Network, Toronto

Comparing 10 approaches for locally advanced or metastatic non-small cell lung cancer

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Sites in London, Montreal and 1 more city

Official title: Phase Ib Study of the Safety of T-DXd and Immunotherapy Agents With and Without Chemotherapy in Advanced or Metastatic HER2+, Non-squamous NSCLC

Locally Advanced or Metastatic Non-Small Cell Lung Cancer · AstraZeneca

Testing Endobronchial ultrasound-guided with Transesophageal ultrasound-guided fine for non-small cell lung cancer

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Sites in London and Toronto

Official title: Chest Lymph Node Sampling in Patients With Advanced Lung Cancer to be Treated With Curative-intent Radiation Treatment

Non-Small Cell Lung Cancer · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Comparing Nivolumab with ctDNA blood test for non small cell lung cancer

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One site, in Toronto

Official title: Using ctDNA to Determine Therapies for Lung Cancer

Non Small Cell Lung Cancer · University Health Network, Toronto

Comparing 7 approaches for non-small cell lung cancer

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Sites in Montreal, Edmonton and 1 more city

Official title: Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

Non-small Cell Lung Cancer · AstraZeneca

Comparing Carboplatin with Stereotactic Body Radiation Therapy for locally advanced lung non-small cell carcinoma

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One site, in Ottawa

Official title: Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

Locally Advanced Lung Non-Small Cell Carcinoma · NRG Oncology

Comparing 8 approaches for advanced or metastatic NSCLC harboring epidermal growth

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One site, in Brampton

Official title: A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.

Advanced or Metastatic NSCLC Harboring Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion (ex20ins) Mutations · Taiho Oncology, Inc.

Comparing Ifinatamab deruxtecan with Topotecan for small cell lung cancer

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Sites in Brampton, Edmonton and 3 more cities