Substance Use Disorder Clinical Trials

Trials for someone you care about with substance use disorder.

Mental Health

Recruiting Drug Device Behavioral Older adults Healthy volunteers

22 trials

Testing Efruxifermin against a placebo for NASH - nonalcoholic steatohepatitis

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Sites in Toronto, Edmonton and 3 more cities

RecruitingPHASE3

Official title: A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

NASH - Nonalcoholic Steatohepatitis · Akero Therapeutics, Inc

Testing Naloxone Hydrochloride with Buprenorphine hydrochloride and for opioid use disorder

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2 sites in Vancouver

RecruitingPHASE4

Official title: Symptom-Inhibited Naloxone Induction (SINI) for Buprenorphine Initiation: A Feasibility Trial

Opioid Use Disorder · Pouya Azar

Testing Bupivacaine-epinephrine for opioid use

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One site, in Hamilton

RecruitingPHASE2

Official title: Timing of TAP Blocks in Bariatric Surgery

Opioid Use · McMaster University

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Testing TOTUM-448 against a placebo for non-alcoholic fatty liver disease

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One site, in Québec

Recruiting

Official title: Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD

Non-Alcoholic Fatty Liver Disease · Valbiotis

Testing Efimosfermin alfa against a placebo for non-alcoholic fatty liver disease

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One site, in Québec

RecruitingPHASE3

Official title: A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH

Non-alcoholic Fatty Liver Disease · GlaxoSmithKline

Testing Pegozafermin against a placebo for metabolic dysfunction-associated steatotic liver disease

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Sites in Toronto, Vancouver and 5 more cities

RecruitingPHASE3

Official title: A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis · 89bio, Inc.

Testing Pegozafermin against a placebo for metabolic dysfunction-associated steatohepatitis (MASH) /

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Sites in Vancouver, Calgary and 5 more cities

RecruitingPHASE3

Official title: A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis · 89bio, Inc.

Testing Standardized Prescription for opioid use

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One site, in Toronto

Recruiting

Official title: Opioid Use Post-Discharge After Ambulatory Distal Arm Surgery

Opioid Use · University Health Network, Toronto

Testing Aurora 1:1 Drops (Indica) against a placebo for opioid use disorder

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One site, in Vancouver

RecruitingPHASE2

Official title: Evaluating Tetrahydrocannabinol as an Adjunct to Opioid Agonist Therapy

Opioid Use Disorder · BC Centre on Substance Use

Testing Psilocybin for alcohol use disorder

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One site, in Calgary

RecruitingPHASE2

Official title: Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder

Alcohol Use Disorder · University of Calgary

Testing deep brain stimulation and for addiction

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One site, in Toronto

Recruiting

Official title: HABITS Study (Helping Addiction by Individualized Therapeutic Stimulation): Pilot Trial of Deep Brain Stimulation Guided By Stereoelectroencephalography for Treatment-Refractory Substance Use Disorders

Addiction · Centre for Addiction and Mental Health

Testing Alcohol Change Course Enhanced for alcohol misuse

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One site, in Regina

Recruiting

Official title: Adaptive Actions and Alcohol Use Outcomes During Internet-delivered Cognitive Behaviour Therapy

Alcohol Misuse · University of Regina

Testing Next Generation Dome Helmet for substance use disorder (SUD)

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One site, in Toronto

Recruiting

Official title: Safety and Feasibility of Next-Generation Dome Helmet (NGDH) for Focused Ultrasound Neuromodulation in Substance Use Disorder (SUD)

Substance Use Disorder (SUD) · Sunnybrook Health Sciences Centre

Testing CBT for alcohol use disorder

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One site, in Toronto

Recruiting

Official title: Phenotyping Patients With Alcohol and Cannabis Use Disorders Using the Addictions Neuroclinical Assessment

Alcohol Use Disorder · Centre for Addiction and Mental Health

Testing Native HEALTH for alcohol drinking

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One site, in Fredericton

Recruiting

Official title: Development of a Culturally Grounded, Trauma-Informed Alcohol Intervention With a Reserve-Dwelling First Nation Group

Alcohol Drinking · University of Rhode Island

Testing Brenipatide against a placebo for opioid use disorder

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Sites in Toronto, Calgary and 5 more cities

RecruitingPHASE2

Official title: A Study of Brenipatide in Participants With Opioid Use Disorder

Opioid Use Disorder · Eli Lilly and Company

Testing Peer support service for substance use disorder (SUD)

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One site, in Vancouver

Recruiting

Official title: Peer Support Workers Feasibility Study

Substance Use Disorder (SUD) · University of British Columbia

Testing Psilocybin-assisted Psychotherapy for opioid dependence

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One site, in Kelowna

RecruitingPHASE2

Official title: Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication

Opioid Dependence · University of British Columbia

Testing GSK4532990 against a placebo for alcoholic liver diseases

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Sites in Toronto, Calgary and 5 more cities

RecruitingPHASE2

Official title: A Study to Investigate the Safety and Efficacy of GSK4532990 Compared With Placebo in Adult Participants Aged 18 to 70 Years With Alcohol-related Liver Disease

Liver Diseases, Alcoholic · GlaxoSmithKline

Testing Buprenorphine/naloxone for opioid-use disorder

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Sites in Vancouver, Edmonton and 1 more city

RecruitingPHASE2

Official title: Evaluating Buprenorphine/Naloxone Microdosing vs. Standard Dosing in Emergency Departments

Opioid-use Disorder · University of British Columbia

Testing Oral solution against a placebo for alcohol use disorder

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One site, in Toronto

RecruitingPHASE2

Official title: Evaluating Cannabidiol as a Novel Anticraving Medication for Alcohol Use Disorder

Alcohol Use Disorder · Centre for Addiction and Mental Health

Testing Alcohol (Ethanol) against a placebo for alcohol consumption

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One site, in Thunder Bay

Recruiting

Official title: Ethanol Consumption in the Heat

Alcohol Consumption · Lakehead University

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.