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Official title: Rollover Study for Participants Who Have Been Treated With and Are Continuing to Benefit From Opnurasib as a Single Agent or in Combination With Other Study Treatments

Locally Advanced or Metastatic KRAS G12C-mutated Non-small Cell Lung Cancer · Novartis Pharmaceuticals

Comparing Calderasib with Pemetrexed for non-small cell lung cancer

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One site, in Edmonton

Official title: A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC

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Testing 225Ac-ETN029 with 111In-ETN029 for small cell lung carcinoma

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One site, in Montreal

Official title: Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors

Small Cell Lung Carcinoma · Novartis Pharmaceuticals

Comparing Telisotuzumab Vedotin with Docetaxel for non small cell lung cancer

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Sites in Brampton, Edmonton and 3 more cities

Official title: A Study to Assess Disease Activity and Adverse Events of Intravenous (IV) Telisotuzumab Vedotin Compared to IV Docetaxel in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Non Small Cell Lung Cancer · AbbVie

Comparing Pumitamig with Pembrolizumab for non-small cell lung cancer (NSCLC)

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Sites in Halifax, Oshawa and 3 more cities

Official title: A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)

Non-Small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb

Comparing Pumitamig with Durvalumab for non-small cell lung cancer (NSCLC)

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Sites in Montreal, Ottawa and 1 more city

Official title: A Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)

Non-small Cell Lung Cancer (NSCLC) · Bristol-Myers Squibb

Comparing Divarasib with Pemetrexed for non-small cell lung cancer

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Sites in Barrie, Brampton and 7 more cities

Official title: A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer · Hoffmann-La Roche

Comparing Calderasib with Pembrolizumab for non-small cell lung cancer

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Sites in Halifax, Hamilton and 4 more cities

Official title: A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC

Testing LY3537982 against a placebo for non-small-cell lung carcinoma

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Sites in Abbotsford British Columbia, Chicoutimi and 1 more city

Official title: A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung · Eli Lilly and Company

Comparing 4 approaches for non-small cell lung cancer

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Sites in Montreal, Ottawa and 1 more city

Official title: A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Non-Small Cell Lung Cancer · Hoffmann-La Roche

Testing Tozorakimab against a placebo for viral lung infection and acute respiratory failure

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Sites in Montreal, Winnipeg and 8 more cities

Official title: Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen

Viral Lung Infection and Acute Respiratory Failure · AstraZeneca

Testing Mycophenolate Mofetil against a placebo for systemic sclerosis with lung involvement

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Sites in Montreal and Québec

Official title: Mycophenolate Mofetil in Systemic Sclerosis With Subclinical Interstitial Lung Disease

Systemic Sclerosis With Lung Involvement · Centre hospitalier de l'Université de Montréal (CHUM)

Comparing 3 approaches for fibrosing interstitial lung disease

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Sites in Calgary and Toronto

Official title: A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD)

Fibrosing Interstitial Lung Disease · Boehringer Ingelheim

Comparing Exertional Oxygen with Education and Support for fibrotic interstitial lung disease

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One site, in Edmonton

Official title: Ambulatory Oxygen Therapy for Individuals With Mild-to-moderate Interstitial Lung Disease

Fibrotic Interstitial Lung Disease · University of Alberta

Testing Oxaliplatin for lung metastases

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One site, in Toronto

Official title: In Vivo Lung Perfusion (IVLP) for Colorectal Cancer Metastatic to Lung

Lung Metastases · University Health Network, Toronto

Comparing 3 approaches for lung cancer

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One site, in Saskatoon

Official title: Evaluation of 89Zr-DFO-nimotuzumab for Non-invasive Imaging of EGFR+ Cancers by Positron Emission Tomography (PET)

Lung Cancer · University of Saskatchewan

Comparing Lazertinib with Carboplatin for non-small-cell lung carcinoma

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One site, in Toronto

Official title: A Study of Neoadjuvant Amivantamab With Either Lazertinib or Chemotherapy in Participants With Resectable EGFR-Mutated NSCLC

Carcinoma, Non-Small-Cell Lung · Janssen Research & Development, LLC

Comparing Calderasib with MK-3475A for non-small cell lung cancer

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Sites in Moncton and Montreal

Official title: MK-3475A±Calderasib (MK-1084) in Completely Resected Stage IIA-IIIB (N2) KRAS G12Cm NSCLC (MK-1084-013)

Non-small Cell Lung Cancer · Merck Sharp & Dohme LLC

Testing Trastuzumab Deruxtecan for non-small cell lung cancer

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One site, in Montreal

Official title: A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer · Memorial Sloan Kettering Cancer Center

Comparing Amivantamab with Olomorasib for non-small-cell lung carcinoma

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One site, in Toronto

Official title: A Study of Amivantamab and Olomorasib Combination Therapy in Participants With Metastatic Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung · Janssen Research & Development, LLC

Comparing Ris-Rez with Topotecan for lung neoplasms

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Sites in Montreal, Ottawa and 1 more city

Official title: A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)

Neoplasms, Lung · GlaxoSmithKline

Comparing 7 approaches for non-squamous non-small cell lung cancer

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Sites in Ottawa and Toronto

Official title: A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

Non-Squamous Non-Small Cell Lung Cancer · AbbVie

Comparing Sacituzumab Govitecan (SG) with Topotecan for extensive stage small cell lung cancer (ES-SCLC)

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Sites in Barrie, Hamilton and 3 more cities

Official title: Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

Extensive Stage Small Cell Lung Cancer (ES-SCLC) · Gilead Sciences

Comparing Sigvotatug Vedotin with Pembrolizumab for non-small cell lung cancer

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Sites in Saint-Jérôme, Abbotsford British Columbia and 1 more city

Official title: This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

Non-Small Cell Lung Cancer · Pfizer

Comparing 4 approaches for NSCLC stage IV

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Sites in Brampton, Kitchener and 5 more cities

Official title: Clinical Trial of N-803 Plus Tislelizumab or Prior Failed Immune Checkpoint Inhibitor and Docetaxel Versus Docetaxel Monotherapy in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Acquired Resistance to Immune Checkpoint In

NSCLC Stage IV · ImmunityBio, Inc.

Testing SMS001 for carcinoma, non-small-cell lung cancer (NSCLC)

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One site, in Toronto

Official title: An Adjuvant Study to Evaluate SMS001 (Paclitaxel) in Non-Small Cell Lung Cancer

Carcinoma, Non-Small-Cell Lung Cancer (NSCLC) · ToLymph Inc.

Comparing BMS-986489 (BMS-986012+Nivolumab) with Atezolizumab for extensive-stage small cell lung cancer

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Sites in Chicoutimi, Edmonton and 2 more cities

Official title: A Study to Compare the Efficacy and Safety of BMS-986489 (BMS-986012+ Nivolumab Fixed Dose Combination) in Combination With Carboplatin Plus Etoposide to That of Atezolizumab With Carboplatin Plus Etoposide as First-Line Therapy in Participants With Extensive-Stage Small Cell Lung Cancer (TIGOS).

Extensive-Stage Small Cell Lung Cancer · Bristol-Myers Squibb

Comparing 5 approaches for lung cancer

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Sites in Montreal, Ottawa and 2 more cities

Official title: A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors

Lung Cancer · Bristol-Myers Squibb

Comparing 8 approaches for non-small cell lung cancer

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Sites in Edmonton, Hamilton and 2 more cities