Comparing obrixtamig with atezolizumab for small cell lung cancer (SCLC)

Inclusion

• +Patients with asymptomatic brain metastasis are eligible if they meet one of the following criteria:
• +Untreated brain metastases that do not require treatment and the patient is neurologically stable without the use of glucocorticoids or therapeutic anti-convulsant for at least 28 days prior to randomisationRandomisedWhich group you go into is decided by chance, not by you or your doctor.Read more →
• +Presence of leptomeningeal disease and/or carcinomatous meningitis
• +Patients with histologically confirmed Extensive-stage Small Cell Lung Cancer (ES-SCLC)
• +Patients without any previous systemic anti-cancer treatment for ES-SCLC. Patients who received previous systemic anti-cancer treatment during limited stage are eligible if the treatment has been completed more than 6 months before the diagnosis of ES-SCLC.
• +Adequate archival formalin-fixed paraffin-embedded (FFPE) tumour tissue, as specified in the Laboratory Manual, must be available for central laboratory analysis of Delta-like ligand 3 (DLL3) expression status and other biomarkersBiomarkerSomething measurable in the body used as a signal of what is happening.Read more →. The central laboratory investigational VENTANA DLL3 (SP347) RxDx test result must be available prior to randomisation.
• +Eastern Cooperative Oncology Group (ECOG) score of 0 or 1
• +Eligible for continuing carboplatin + etoposide + atezolizumab regimen as first-line Standard of careStandard of careThe treatment normally given for a condition outside a study.Read more → (SoC) treatment within 28 days after the start of the initial cycle of standard therapy
• +Eligible to receive treatment with full dose of atezolizumab, carboplatin, and etoposide as first-line SoC treatment, in accordance with the approved Summary of Product Characteristics if provided centrally or approved local product label if provided by the trial siteTrial siteA hospital or clinic where a study is actually run.Read more → Further inclusion criteriaInclusion criteriaThe things you must have or be for a study to consider you.Read more → apply.
• +Exclusion CriteriaExclusion criteriaThe things that would prevent someone from taking part.Read more → :
• +Previous treatment targeting DLL3 (e.g. T cell engagers (TcEs), cell therapies, antibody-drug conjugates, or radiopharmaceuticals)
• +Radiotherapy of any anatomical site within 7 days prior to randomisation
• +Toxicity from previous treatments that has not resolved to ≤ Common Terminology Criteria for Adverse EventsAdverse eventAny medical problem that happens during a study, whether or not the treatment caused it.Read more → (CTCAE) Grade 1 or baselineBaselineYour starting measurements, taken before treatment begins.Read more →. Patients with alopecia, any grade, CTCAE ≤Grade 2, asthenia/fatigue, amenorrhea/menstrual disorders any grade, CTCAE Grade ≤2 peripheral neuropathy, and/or CTCAE Grade 2 endocrinopathies controlled by replacement therapy, and toxicities, which are considered irreversible but stable for at least 4 weeks prior to randomisation, per investigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more → judgment may be eligible. Note: Patients who developed toxicity from the cycle of standard therapy received prior to randomisation are eligible if adequate organ function is ensured as described
• +Patient with active autoimmune disease or a documented history of autoimmune disease that requires systemic treatment (e.g. glucocorticoids or immunosuppressive drugs). Patients with vitiligo, resolved childhood asthma/atopy, alopecia, or any chronic skin condition that does not require systemic therapy, patients with autoimmune-related hypothyroidism on a stable dose of thyroid replacement hormone and/or controlled Type 1 diabetes mellitus on a stable insulin regimen may be included if in the opinion of the investigator it is appropriate and safe to do so.
• +Further exclusion criteria apply.
• +Treatment for brain metastases (e.g. whole brain radiation therapy, stereotactic radiotherapy, or radiosurgery) completed at least 7 days prior to randomisation and the patient is neurologically stable without the use of glucocorticoids or therapeutic anti-convulsant for at least 7 days prior to randomisation