Testing SMIP against a placebo for mild cognitive impairment

Exclusion

• −Self-reported having either of the following:
• −Current post-traumatic stress disorder and/or generalized anxiety disorder; Substance use disorder; Significant heart disease (i.e., stroke occurring during 5 years prior to study assessment or cardiac disease non-stabilized with medication); Severe Depression, or a Geriatric Depression Scale (GDS) score greater than 12; Current insomnia disorder.
• −Current medications for sleep problems, or use of medications that affect sleep.
• −Use of antidepressant and anti-anxiety medication for less than 3 months prior to study entry.
• −Use of analgesics with codeine (or other opioids).
• −Use of antipsychotic medication (past or current).
• −Self-reported colour-blindness.
• −General anesthesia in the past year.
• −Suspected or confirmed traumatic brain injury during the last 24 months.
• −Motion sickness or intolerant to virtual reality tasks.
• −Cholesterol or hypertension medication for less than 3 months or changes expected within the next 9 months.
• −History or presence of neurological or psychiatric disorders (other than MCI) that in the opinion of the investigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more → may compromise patient safety or study objectives.
• −Current severe medical conditions (e.g. untreated diabetes, cancer) that in the opinion of the investigator may compromise patient safety or study objectives.
• −For female participants, severe menopausal symptoms, including hot flashes (determined from the Greene climacteric scale - any participants scoring over 15 is excluded).
• −Use of computer games that are designed to help with memory or general cognition.
• −Presence of any medical or psychological condition that, in the opinion of the principal investigator, may compromise the study objectives.
• −Presence of contra-indications for MRI scanning.
• −Having undergone brain surgery or ECT.
• −Current smoker.