Comparing 3 approaches for protein metabolism
Official title: Animal and Microbial-based Dietary Protein Efficiency in Adults
The Effects of Animal- and Microbial-based Protein Sources on Whole-body Protein Metabolism in Healthy Adults
- 3 groups
- One site, in Toronto
- Recruiting
Interventions
- Other intervention
Yeast Protein Supplement
Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
- Other intervention
Whey Protein Isolate Supplement
Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
- Other intervention
Collagen Hydrolysate Supplement
Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
Canadian Sites (1)
1 of 1 recruiting
- Recruiting
Kinesiology & Physical Education
Toronto, Ontario
Eligibility Criteria
See who this study is looking for14 criteria
The trial’s own eligibility text, word for word from the registry. Only the trial site can say who takes part.
Inclusion
- +Participants will be aged 18-45 years old.
- +Self-reported regular menstrual cycle (25-35d) within the last 3 months (female participants).
- +Healthy, male and female, recreationally-active participants.
- +Healthy will be defined as screenedScreeningThe checks done before joining, to see whether a study fits.Read more → by the PAR-Q+ (Appendix B) and The Physical Activity Readiness Questionnaire (Appendix C).
- +Participants are willing to abide by the compliance rules of this study.
- +Use of monophasic combined oral contraceptives (COC) containing 21 active pills (e.g., Yaz, Marvelon, Cyclen, etc.; the brand of COC will be recorded) (female participants).
Exclusion
- −Inability to adhere to any of the compliance rules judged by principal investigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more → (e.g. dairy protein or yeast allergy).
- −Self-reported illicit drug use (e.g., growth hormone, testosterone, etc.).
- −Individuals who have participated in studies within the past year involving any of the stable isotopes in the study.
- −Use of multiphasic COCs due to the difficulty of controlling for hormonal fluctuations in such formulations (female participants).
- −Use of COCs containing \>21 active pills per cycle due to potential differences in their effect on metabolism (female participants).
- −Not currently or previously (in the past 6 months) on a vegan diet
- −Use of other forms of hormonal contraception (e.g., progestin-only pill, hormonal IUD, intravaginal ring) (female participants).
- −Self-reported regular tobacco use.
In plain language
Assembled directly from this trial’s registry record. Every sentence traces to a field below — nothing here is generated or interpreted.
What this study is
This study is investigating how something functions in the body, rather than testing a treatment directly.
This study is not organised into the usual phase numbers — that is common for device, behavioural, and diagnostic research.
From the trial registry
Built from these fields:
- designModule.designInfo.primaryPurpose
- designModule.phases
Who receives what
There are 3 groups in this study.
Group A receives Yeast Protein Supplement.
Registry label: A: Yeast Protein Supplement
Group B, the comparison group, receives Whey Protein Isolate Supplement.
Registry label: B: Whey Protein Isolate Supplement
Group C, the comparison group, receives Collagen Hydrolysate Supplement.
Registry label: C: Collagen Hydrolysate Supplement
From the trial registry
Built from these fields:
- armsInterventionsModule.armGroups[].label
- armsInterventionsModule.armGroups[].type
- armsInterventionsModule.armGroups[].interventionNames
How the study is run
Which group you would be placed in is decided by chance, like a coin flip — not by you and not by your doctor.
One group of people involved — usually the participants — is not told which treatment is which.
From the trial registry
Built from these fields:
- designModule.designInfo.allocation
- designModule.designInfo.maskingInfo.masking
Is there a placebo?
This study does not list a placeboPlaceboA dummy treatment with no active medicine, used for comparison.Read more → group.
One group receives an existing treatment, so the two can be compared.
From the trial registry
Built from these fields:
- armsInterventionsModule.armGroups[].type
- armsInterventionsModule.armGroups[].interventionNames
Who the study is looking for
The study lists an age range of 18 years to 45 years.
The study is open to people of any sex.
The study accepts healthy volunteersHealthy volunteerSomeone without the condition being studied who takes part anyway.Read more → as well as people with the condition.
These are the criteria the study lists. Only the trial siteTrial siteA hospital or clinic where a study is actually run.Read more → can decide whether someone can take part.
From the trial registry
Built from these fields:
- eligibilityModule.minimumAge
- eligibilityModule.maximumAge
- eligibilityModule.sex
- eligibilityModule.healthyVolunteers
How big and how long
The study aims to enrol about 13 people.
The study is currently expected to finish around December 2025.
The main measurement is taken over: 8 hours.
From the trial registry
Built from these fields:
- designModule.enrollmentInfo.count
- statusModule.completionDateStruct.date
- outcomesModule.primaryOutcomes[].timeFrame
What the study measures
1. Phenylalanine excretion (umol/kg/h) — measured over 8 hours.
Phenylalanine oxidation (umol/kg/h) — measured over 8 hours.
From the trial registry
Built from these fields:
- outcomesModule.primaryOutcomes[].measure
- outcomesModule.primaryOutcomes[].timeFrame
Source: NCT07148908 on ClinicalTrials.gov. The full registry text is further down this page — this summary never replaces it.
Not medical advice. What do these terms mean?
What is being tested — in plain terms
About Yeast Protein SupplementDietary supplement
Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
From the trial registry — its own words, unedited.
What a dietary supplement is here: A vitamin, mineral, or other supplement being studied.
Read the full explanation → · in clinical review
About Whey Protein Isolate SupplementDietary supplement
Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
From the trial registry — its own words, unedited.
What a dietary supplement is here: A vitamin, mineral, or other supplement being studied.
Read the full explanation → · in clinical review
About Collagen Hydrolysate SupplementDietary supplement
Each protein will be consumed at 0.9g/kg/d in n=8 hourly drinks
From the trial registry — its own words, unedited.
What a dietary supplement is here: A vitamin, mineral, or other supplement being studied.
Read the full explanation → · in clinical review
Common questions
Answered from this trial’s registry record. Where the record doesn’t say, these answers say so rather than filling the gap.
Am I eligible for this trial?
Only the trial siteTrial siteA hospital or clinic where a study is actually run.Read more → can decide whether someone can take part. Concord cannot make that determination, and neither can any tool that has not examined you.
What the study lists: an age range of 18 years to 45 years.
The full inclusionInclusion criteriaThe things you must have or be for a study to consider you.Read more → and exclusion criteriaExclusion criteriaThe things that would prevent someone from taking part.Read more → are published on this page, exactly as the study team wrote them.
The useful next step is to bring this trial to your doctor. Answering a few questions first gives them something concrete to review.
From the trial registry
- eligibilityModule.minimumAge
- eligibilityModule.maximumAge
- eligibilityModule.eligibilityCriteria
Is there a placebo?
This study does not list a placeboPlaceboA dummy treatment with no active medicine, used for comparison.Read more → group.
One group receives an existing treatment so the two can be compared.
From the trial registry
- armsInterventionsModule.armGroups[].type
Would I know which treatment I am getting?
One group of people involved — usually the participants — is not told which treatment is which.
Which group you would be placed in is decided by chance, like a coin flip — not by you and not by your doctor.
From the trial registry
- designModule.designInfo.maskingInfo.masking
- designModule.designInfo.allocation
Who can join?
The study lists an age range of 18 years to 45 years.
It is open to people of any sex.
It accepts healthy volunteersHealthy volunteerSomeone without the condition being studied who takes part anyway.Read more → as well as people with the condition.
Only the trial siteTrial siteA hospital or clinic where a study is actually run.Read more → can confirm whether a particular person can take part.
From the trial registry
- eligibilityModule.minimumAge
- eligibilityModule.maximumAge
- eligibilityModule.sex
- eligibilityModule.healthyVolunteers
How long would this take?
The study's main measurement is taken over: 8 hours.
The study as a whole is currently expected to finish around 2025-12-31.
How long any one person takes part can differ from the study length. The study team can tell you what the schedule looks like in practice.
From the trial registry
- outcomesModule.primaryOutcomes[].timeFrame
- statusModule.completionDateStruct.date
How many people are taking part?
The study aims to enrol about 13 people.
From the trial registry
- designModule.enrollmentInfo.count
Where is this happening?
This study lists one location: Toronto, Ontario, Canada.
Sites can open and close during a study, so confirm with the team before travelling.
From the trial registry
- trial_locations
About This Trial
Given the relatively high carbon footprint and sustainability of animal-based proteins, there is a growing interest in determining the nutritional quality non-animal-based protein sources. The overall objective of this investigation is to examine the impact of different animal and microbial-based protein sources to support whole body protein synthesis in adults. To do this, investigators will employ a 'breath test' method developed in our laboratory as well as urine sampling. The results of this study will allow us to better understand the impact of dietary protein quality for maintaining health and body protein mass in adults.
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See if this trial could fit youThis page is for informational purposes only and does not constitute medical advice. Clinical trial eligibility can only be determined by the trial site after proper screening. Trial information is sourced from ClinicalTrials.gov and may not reflect the most current status. Always consult your healthcare provider before making decisions about clinical trial participation.