Major Depressive Disorder Clinical Trials

Trials for someone you care about with major depressive disorder.

Mental Health

Recruiting Drug Device Behavioral Older adults Healthy volunteers

17 trials

Comparing Ketogenic Diet with Canadian Food Guide-Aligned Diet for major depressive disorder (MDD)

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There are 2 groups in this study. Group A receives Ketogenic Diet, together with one or more of: Accelerated Intermittent Theta Burst Stimulation (iTBS). Group B, the comparison group, receives Canadian Food Guide-Aligned Diet, together with one or more of: Accelerated Intermittent Theta Burst Stimulation (iTBS).

One site, in Toronto

2 groups
One site, in Toronto
Recruiting

Official title: Ketogenic Diet and Neuromodulation in Treatment Resistant Depression

Major Depressive Disorder (MDD) · Sunnybrook Health Sciences Centre

Comparing Things You Do Program (Ultra-Brief ICBT) with Things You Do Program Plus Personalized for depression

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There are 2 groups in this study. Group A, the comparison group, receives Things You Do Program (Ultra-Brief ICBT). Group B receives Things You Do Program Plus Personalized Feedback.

One site, in Regina

2 groups
One site, in Regina
Recruiting

Official title: An Ultra-Brief ICBT Intervention: The 'Things You Do' Program

Depression · University of Regina

Testing PSP Wellbeing Course for anxiety depression

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Everyone in this study is in one group and receives PSP Wellbeing Course.

One site, in Regina

1 group
One site, in Regina
Recruiting

Official title: Internet-Delivered Cognitive Behaviour Therapy for Public Safety Personnel

Depression, Anxiety · University of Regina

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Testing dialectical behavior therapy for depression - major depressive disorder

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Everyone in this study is in one group and receives dialectical behavior therapy.

One site, in Windsor

1 group
One site, in Windsor
Recruiting

Official title: Feasibility and Acceptability of an E-learning Dialectical Behavior Therapy Skills Course

Depression - Major Depressive Disorder · University of Windsor

Testing Building Regulation in Dual Generations for maternal depression

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There are 2 groups in this study. Group A receives Building Regulation in Dual Generations (BRIDGE; DBT + Parenting). Group B receives no study treatment and is followed for comparison.

Sites in Montreal and Winnipeg

2 groups
Sites in Winnipeg and Montreal
Recruiting

Official title: Enhancing Preschool Children's Attention and Behaviour: Parent-Focused Program

Maternal Depression · McGill University

Testing Acceptance and Commitment Therapy with Ketamine for depression - major depressive disorder

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Everyone in this study receives Ketamine and Acceptance and Commitment Therapy.

One site, in Montreal

1 group
One site, in Montreal
Recruiting

Official title: ACT_for Alcohol Use Disorder and Depression

Depression - Major Depressive Disorder · Centre hospitalier de l'Université de Montréal (CHUM)

Comparing Ketamine hydrochloride with Midazolam Hydrochloride for major depressive disorder

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There are 2 groups in this study. Group A receives one or more of: Ketamine hydrochloride and i-CBT (Internet-based Cognitive Behavioural Therapy). Group B, the comparison group, receives one or more of: i-CBT (Internet-based Cognitive Behavioural Therapy) and Midazolam Hydrochloride.

One site, in Toronto

Phase 2
2 groups
One site, in Toronto
Recruiting

Official title: i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial

Major Depressive Disorder · University Health Network, Toronto

Comparing e-CBT with e-CBT + Phone Call for depression

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There are 2 groups in this study. Group A receives one or more of: e-CBT, e-CBT + Phone Call and e-CBT + Phone Call + Pharmacotherapy. Group B, the comparison group, receives one or more of: e-CBT, e-CBT + Phone Call and e-CBT + Phone Call + Pharmacotherapy.

One site, in Kingston

2 groups
One site, in Kingston
Recruiting

Official title: Comparing Clinical Decision-making of AI Technology to a Multi-professional Care Team in ECBT for Depression

Depression · Dr. Nazanin Alavi

Comparing 3 approaches for depression

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There are 3 groups in this study. Group A receives Wellbeing Course for Students (Fast Track). Group B receives Wellbeing Course for Students (5 weeks). Group C receives Wellbeing Course (8 weeks).

One site, in Regina

3 groups
One site, in Regina
Recruiting

Official title: Internet-delivered Cognitive Behaviour Therapy for Students: Duration Preference Trial

Depression · University of Regina

Comparing Cognitive Behavioral Therapy with Pharmacotherapy for major depressive disorder

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There are 2 groups in this study. Group A receives Cognitive Behavioral Therapy. Group B receives Pharmacotherapy.

One site, in Halifax

Phase 4
2 groups
One site, in Halifax
Recruiting

Official title: Personalized Indications for CBT and Antidepressants in Treating Depression

Major Depressive Disorder · Nova Scotia Health Authority

Testing The Building Emotional Awareness and for anxiety depression

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Everyone in this study is in one group and receives The Building Emotional Awareness and Mental Health (BEAM) Program.

One site, in Winnipeg

1 group
One site, in Winnipeg
Recruiting

Official title: Building Emotional Awareness and Mental Health (BEAM) 2024-2027

Depression, Anxiety · Leslie E. Roos

Comparing 4 approaches for depression

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There are 4 groups in this study. Group A receives Tunneled Delivery and Standard Resources, together with one or more of: Transdiagnostic Self-Guided ICBT. Group B receives Tunneled Delivery and Enhanced Social Learning Resources, together with one or more of: Transdiagnostic Self-Guided ICBT. Group C receives Personalized Delivery and Standard Resources, together with one or more of: Transdiagnostic Self-Guided ICBT. …and 1 more groups.

One site, in Regina

4 groups
One site, in Regina
Recruiting

Official title: Assessing Social Learning and Course Delivery Timing in Internet-delivered Cognitive Behaviour Therapy for Public Safety Personnel

Depression · University of Regina

Testing PA program - MoveU.HappyU for treatment-resistant depression

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There are 2 groups in this study. Group A receives PA program - MoveU.HappyU. Group B receives no study treatment and is followed for comparison.

One site, in Toronto

2 groups
One site, in Toronto
Recruiting

Official title: Physical Activity Program for TRD

Treatment-resistant Depression · Unity Health Toronto

Testing Attachment and Child Health (ATTACH) for depression

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Everyone in this study is in one group and receives Attachment and Child Health (ATTACH) Parenting Program.

One site, in Calgary

1 group
One site, in Calgary
Recruiting

Official title: Adaptation and Pilot Testing of Web and Mobile Interface for the ATTACH™ Intervention

Depression · University of Calgary

Comparing ADAPT Treatment with Incredible Years Parenting Program for depression / major depressive disorder

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There are 2 groups in this study. Group A receives ADAPT Treatment. Group B, the comparison group, receives Incredible Years Parenting Program (IYPP).

One site, in Toronto

2 groups
One site, in Toronto
Recruiting

Official title: Optimizing Treatment for Depressed Parents of Children With Emotional and Behavioural Problems

Depression / Major Depressive Disorder · University of Toronto

Comparing Repetitive Transcranial Magnetic with Research Interview, Questionnaires for major depressive disorder

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There are 2 groups in this study. Group A receives one or more of: Repetitive Transcranial Magnetic Stimulation, Research Interview, Questionnaires, Brain Scan and Saliva Samples. Group B receives one or more of: Research Interview, Questionnaires, Brain Scan and Saliva Samples.

One site, in Toronto

2 groups
One site, in Toronto
Recruiting

Official title: The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression

Major Depressive Disorder · Unity Health Toronto

Comparing Traditional Country Foods with Cultural Workshops for anxiety depression

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There are 2 groups in this study. Groups A and B receive one or more of: Traditional Country Foods and Cultural Workshops.

2 sites in Arviat

Early Phase 1
2 groups
2 sites in Arviat
Recruiting

Official title: Integrating Inuit Knowledge Principles in Multi-Level Mental Health Clinical Trials

Depression, Anxiety · University of Alberta

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.