Major Depressive Disorder Clinical Trials

Trials for someone you care about with major depressive disorder.

Mental Health

Recruiting Drug Device Behavioral Older adults Healthy volunteers

18 trials

Testing Dextromethorphan-Bupropion for major depressive disorder (MDD)

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One site, in Toronto

RecruitingPHASE2

Official title: Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder

Major Depressive Disorder (MDD) · Roger McIntyre

Testing Psilocybin for treatment-resistant depression

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2 sites in Toronto

RecruitingPHASE2

Official title: Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression

Treatment-Resistant Depression · Centre for Addiction and Mental Health

Comparing 3 approaches for major depressive disorder

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Sites in Calgary, Kingston and 3 more cities

RecruitingPHASE3

Official title: A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder · Neurocrine Biosciences

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Testing NBI-1065845 against a placebo for major depressive disorder

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Sites in Toronto and Verdun

RecruitingPHASE3

Official title: NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder · Neurocrine Biosciences

Testing Apo-levocarb for major depressive disorder

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One site, in Vancouver

RecruitingPHASE2

Official title: Measuring Psychomotor Response to L-DOPA Challenge As a Biomarker for Outcomes in Late-Life Depression: a Pilot Feasibility Trial

Major Depressive Disorder · University of British Columbia

Testing Escitalopram against a placebo for major depressive disorder

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Sites in Toronto, Calgary and 7 more cities

RecruitingPHASE4

Official title: Optimized Predictive Treatment In Medications for Unipolar Major Depression (OPTIMUM-D)

Major Depressive Disorder · Nova Scotia Health Authority

Comparing Ketamine with ECT for treatment resistant depression

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One site, in Saskatoon

RecruitingPHASE4

Official title: ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression

Treatment Resistant Depression · University of Saskatchewan

Testing Brenipatide against a placebo for major depressive disorder

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Sites in Québec, Calgary and 10 more cities

RecruitingPHASE3

Official title: A Study of Brenipatide in Adult Participants With Major Depressive Disorder

Depressive Disorder, Major · Eli Lilly and Company

Testing Acceptance and Commitment Therapy with Ketamine for depression - major depressive disorder

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One site, in Montreal

Recruiting

Official title: ACT_for Alcohol Use Disorder and Depression

Depression - Major Depressive Disorder · Centre hospitalier de l'Université de Montréal (CHUM)

Testing VLS-01-203 BU against a placebo for treatment resistant depression

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Sites in Kingston and Surrey

RecruitingPHASE2

Official title: A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

Treatment Resistant Depression · atai Therapeutics, Inc.

Testing Psilocybin for treatment resistant depression

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One site, in Toronto

RecruitingPHASE2

Official title: Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)

Treatment Resistant Depression · Centre for Addiction and Mental Health

Comparing Ketamine hydrochloride with Midazolam Hydrochloride for major depressive disorder

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One site, in Toronto

RecruitingPHASE2

Official title: i-CBT and IV Ketamine for Suicidality in Treatment-Resistant Depression: A Randomized, Midazolam-Controlled Clinical Trial

Major Depressive Disorder · University Health Network, Toronto

Testing Brexpiprazole for bipolar depression

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Sites in Montreal and Hamilton

RecruitingPHASE3

Official title: Brexpiprazole Treatment for Bipolar I Depression

Bipolar Depression · Douglas Mental Health University Institute

Comparing Cognitive Behavioral Therapy with Pharmacotherapy for major depressive disorder

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One site, in Halifax

RecruitingPHASE4

Official title: Personalized Indications for CBT and Antidepressants in Treating Depression

Major Depressive Disorder · Nova Scotia Health Authority

Testing NBI-1065845 for major depressive disorder

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One site, in Toronto

RecruitingPHASE3

Official title: Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Major Depressive Disorder · Neurocrine Biosciences

Comparing Oculus VR headset with Ketamine for treatment resistant depression

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One site, in Toronto

RecruitingPHASE3

Official title: InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression

Treatment Resistant Depression · Sunnybrook Health Sciences Centre

Testing Seltorexant against a placebo for major depressive disorder

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One site, in North Vancouver

RecruitingPHASE3

Official title: A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

Depressive Disorder, Major · Janssen Research & Development, LLC

Comparing Risperidone with Psilocybin for treatment resistant depression

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One site, in Toronto

RecruitingPHASE2

Official title: Imaging the Effects of Serotonin 2A Receptor Modulation on Synaptic Density in Treatment-resistant Depression (SYNVEST)

Treatment Resistant Depression · Centre for Addiction and Mental Health

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.