Schizophrenia Clinical Trials

Trials for someone you care about with schizophrenia.

Mental Health

Recruiting Drug Device Behavioral Older adults Healthy volunteers

20 trials

Comparing KarXT with KarX-EC for schizophrenia

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There are 2 groups in this study. Group A receives KarXT. Group B receives KarXT and KarX-EC.

Sites in Calgary, Edmonton and 3 more cities

Phase 3
2 groups
Sites in Calgary, Edmonton and 3 more cities
Recruiting

Official title: A Study to Evaluate the Long-term Safety and Tolerability of Xanomeline and Trospium Chloride for the Treatment of Psychiatric Disorders in Children and Adolescents

Schizophrenia · Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Comparing Magnetic Seizure Therapy with Electroconvulsive Therapy for treatment resistant schizophrenia

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There are 2 groups in this study. Group A receives Magnetic Seizure Therapy (MST). Group B, the comparison group, receives Electroconvulsive Therapy (ECT).

Sites in Toronto and Vancouver

2 groups
Sites in Vancouver and Toronto
Recruiting

Official title: Magnetic Seizure Therapy for Schizophrenia - Trial

Treatment Resistant Schizophrenia · Centre for Addiction and Mental Health

Testing KarXT against a placebo for psychosis associated with Alzheimer's disease

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There are 2 groups in this study. Group A receives KarXT. Group B, the placebo group, receives Placebo.

Sites in Calgary, Hamilton and 4 more cities

Phase 3
2 groups
Sites in Calgary, Hamilton and 4 more cities
Recruiting

Official title: A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-2)

Psychosis Associated With Alzheimer's Disease · Karuna Therapeutics, Inc., a Bristol Myers Squibb company

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Testing KarXT for psychosis associated with Alzheimer's disease

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Everyone in this study is in one group and receives KarXT.

Sites in Calgary, Hamilton and 3 more cities

Phase 3
1 group
Sites in Calgary, Hamilton and 3 more cities
Recruiting

Official title: Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Psychosis Associated With Alzheimer's Disease · Karuna Therapeutics, Inc., a Bristol Myers Squibb company

Testing ML-007C-MA against a placebo for psychosis associated with Alzheimer's disease

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There are 2 groups in this study. Group A receives ML-007C-MA. Group B, the placebo group, receives Placebo.

Sites in Brampton, Lévis and 2 more cities

Phase 2
2 groups
Sites in Brampton, London and 2 more cities
Recruiting

Official title: A Study to Assess the Efficacy and Safety of ML-007C-MA for the Treatment of Alzheimer's Disease Psychosis

Psychosis Associated With Alzheimer's Disease · MapLight Therapeutics

Testing d-DBT for clinical high risk for psychosis (CHR)

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There are 2 groups in this study. Group A receives d-DBT. Group B receives no study treatment and is followed for comparison.

One site, in Toronto

2 groups
One site, in Toronto
Recruiting

Official title: Digital Dialectical Behavioural Therapy (d-DBT) for Youth at Clinical High Risk (CHR) for Psychosis

Clinical High Risk for Psychosis (CHR) · Centre for Addiction and Mental Health

Testing REFLECT: REFlecting on and Learning to for schizophrenia spectrum & other psychotic disorders

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Everyone in this study is in one group and receives REFLECT: REFlecting on and Learning to Evaluate Core beliefs in real Time.

One site, in Scarborough Village

1 group
One site, in Scarborough Village
Recruiting

Official title: REFLECT: A Novel Group-Based Compassion-Focussed Cognitive Behavioural Approach to Core Beliefs in Psychosis

Schizophrenia Spectrum & Other Psychotic Disorders · University of Toronto

Testing Metformin for psychosis

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Everyone in this study is in one group and receives Metformin.

Sites in Halifax and St. John's

Phase 4
1 group
Sites in St. John's and Halifax
Recruiting

Official title: Cannabis Potency Effects on Brain White Matter in Early Phase Psychosis

Psychosis · Nova Scotia Health Authority

Testing Intranasal insulin for schizophrenia

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There are 2 groups in this study. Groups A and B receive one or more of: Intranasal insulin and Placebo.

One site, in Toronto

2 groups
One site, in Toronto
Recruiting

Official title: Does Abnormal Insulin Action in the Brain Underlie Cognitive and Metabolic Dysfunction in Schizophrenia

Schizophrenia · Centre for Addiction and Mental Health

Comparing 3 approaches for schizophrenia

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There are 3 groups in this study. Group A receives one or more of: Cognitive Behavioural Therapy for Psychosis (CBTp) and Sham Cognitive Remediation. Group B receives Befriending, together with one or more of: Cognitive Remediation Therapy (CR). Group C receives one or more of: Cognitive Behavioural Therapy for Psychosis (CBTp) and Cognitive Remediation Therapy (CR).

Sites in Scarborough Village and Whitby

3 groups
Sites in Scarborough Village and Whitby
Recruiting

Official title: Outcomes From Remediation and Behavioural Intervention Techniques

Schizophrenia · University of Toronto

Comparing 3 approaches for schizophrenia

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There are 3 groups in this study. Groups A and B receive Non-invasive brainstem modulation device (stimulation Randomized). Group C receives Non-invasive brainstem modulation device (stimulation-Open Label).

One site, in Toronto

3 groups
One site, in Toronto
Recruiting

Official title: Neuromodulation for Schizophrenia

Schizophrenia · Scion NeuroStim

Testing Cognitive Enhancement Therapy for psychosis

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There are 2 groups in this study. Group A receives no study treatment and is followed for comparison. Group B receives Cognitive Enhancement Therapy (CET).

One site, in Halifax

2 groups
One site, in Halifax
Recruiting

Official title: Piloting of an Intervention to Reduce Problematic Alcohol Use in Early Phase Psychosis Patients

Psychosis · Nova Scotia Health Authority

Testing N-Acetylcysteine against a placebo for prodromal schizophrenia

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There are 2 groups in this study. Group A receives N-Acetylcysteine. Group B, the placebo group, receives Placebo.

One site, in Toronto

2 groups
One site, in Toronto
Recruiting

Official title: Effects of NAC on Symptoms of CHR Patients

Prodromal Schizophrenia · Centre for Addiction and Mental Health

Testing Clozapine for schizophrenia

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There are 2 groups in this study. Group A receives Clozapine. Group B receives no study treatment and is followed for comparison.

One site, in Toronto

Phase 4
2 groups
One site, in Toronto
Recruiting

Official title: Switching From Twice-Daily to Once-Daily Clozapine Dosing in Schizophrenia

Schizophrenia · Centre for Addiction and Mental Health

Testing Active Intermittent Theta Burst against a placebo for clinical high risk for psychosis (CHR)

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There are 2 groups in this study. Group A receives Active Intermittent Theta Burst Stimulation (BEAM-F3 Targeting). Group B, the sham group, receives Sham Comparator: Sham iTBS.

One site, in Verdun

2 groups
One site, in Verdun
Recruiting

Official title: Accelerated Neuromodulation Therapy and Neurocomputational Biomarkers in Individuals at Clinical High Risk for Psychosis

Clinical High Risk for Psychosis (CHR) · Douglas Mental Health University Institute

Testing Medium chain triglyceride oil for first episode psychosis

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Everyone in this study is in one group and receives Medium chain triglyceride oil.

One site, in Sherbrooke

1 group
One site, in Sherbrooke
Recruiting

Official title: Recovery With Exogenous Ketones and Antipsychotics

First Episode Psychosis · Université de Sherbrooke

Testing maCBT for schizophrenia

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There are 2 groups in this study. Group A receives maCBT. Group B receives no study treatment and is followed for comparison.

2 sites in Halifax

2 groups
2 sites in Halifax
Recruiting

Official title: Skills for Wellness

Schizophrenia · Nova Scotia Health Authority

Testing Neuronavigated Intermittent Theta Burst against a placebo for schizophrenia and predominant negative symptoms

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There are 3 groups in this study. Group A receives Neuronavigated Intermittent Theta Burst Stimulation. Group B receives BEAM-F3 Intermittent theta burst stimulation. Group C, the sham group, receives Sham Intermittent Theta Burst Stimulation.

Sites in Montreal, Québec and 1 more city

3 groups
Sites in Montreal, Québec and 1 more city
Recruiting

Official title: Accelerated Neuromodulation Therapy for Negative Symptoms of Schizophrenia

Schizophrenia and Predominant Negative Symptoms · Douglas Mental Health University Institute

Testing Risperidone with Olanzapine for schizophrenia and related disorders

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There are 2 groups in this study. Group A receives one or more of: Risperidone, Olanzapine and paliperidone. Group B receives no study treatment and is followed for comparison.

One site, in Toronto

Phase 4
2 groups
One site, in Toronto
Recruiting

Official title: "Extended" (Alternate Day) Antipsychotic Dosing

Schizophrenia and Related Disorders · Centre for Addiction and Mental Health

Testing Action-Based Cognitive Remediation for psychosis

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There are 2 groups in this study. Group A receives no study treatment and is followed for comparison. Group B receives Action-Based Cognitive Remediation.

Sites in Halifax and St. John's

2 groups
Sites in St. John's and Halifax
Recruiting

Official title: Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis

Psychosis · Nova Scotia Health Authority

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Concord provides information support only. Trial listings come from public registries; eligibility is always determined by the trial site and your care team.