Comparing Endoscopic polypectomy in clinic with Endoscopic Sinus Surgery for sinusitis

Exclusion

• −Diagnosis of allergic fungal sinusitis
• −Allergy, hypersensitivity, or contraindication to the use of local or topical lidocaine anesthetics, nasal topical 1:1000 adrenaline, nasal decongestants, nasal steroid spray
• −Patients with hyperplastic polyps or polyps large enough that they result in external nasal deformity
• −Facial pain/pressure score higher than 2 on the sinonasal outcome test SNOT-22 at the screening visitScreeningThe checks done before joining, to see whether a study fits.Read more →.
• −History of any surgical procedure that prevents the ability to accurately grade the nasal polyps
• −Participants who will not be able to complete the follow-upFollow-upContinued check-ins after the treatment part is finished.Read more → appointments/evaluations
• −Have significant oral structural abnormalities, e.g. unrepaired cleft palate
• −Septal deviation requiring correction in order to perform either EPIC or ESS procedures
• −Diagnosis of an immunodeficiency or immunocompromised state
• −Diagnosis of cystic fibrosis
• −History of either Churg-Strauss syndrome, primary ciliary dyskinesia, or vasculitis (e.g. granulomatosis with polyangiitis(GPA))
• −Any serious or unstable concurrent disease, psychiatric disorder, or any significant condition that, in the opinion of the investigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more →, could confound the results of the study or could interfere with the participant's participation or compliance with the study
• −A recent (within 1 year of the screening visit) clinically significant history of drug or alcohol abuse, or dependence that, in the opinion of the investigator could interfere with the participant's participation or compliance with the study
• −Inability to read and understand English
• −Any medical condition that in the opinion of the investigator would interfere with the treatment
• −Current participation in another clinical trialInterventional studyA study where participants are given something to see what happens.Read more → at the time of the screening visit.
• −Participant is unable to undergo an awake procedure
• −Diagnosis or Aspirin Exacerbated Respiratory Disease (AERD)
• −Women who are pregnant or breast feeding as per patient's report
• −Contraindication to the use of oral corticosteroids (e.g. uncontrolled diabetes, congestive heart failure, uncontrolled hypertension, known renal insufficiency, known peptic ulcer disease, known glaucoma, pregnancy)
• −Any participant who is unfit to undergo surgery under general anesthesia