Comparing 14 approaches for atopic dermatitis

Exclusion

• −Significant allergic or autoimmune diseases, other than AD and well controlled mild to moderate including but not limited to: SLE or other complement disorders; Type 1 diabetes; IBD; Multiple Sclerosis.
• −History of significant allergic reactions, including anaphylaxis and reactions to protein therapeutics, including hypersensitivity to PF-07275315 or PF-07264660 or to the excipients of the formulated drug products. Participants with significant reactions to single, identified, avoidable allergens (eg, peanut allergy) may be eligible if avoidance of these allergens during the study is feasible.
• −HIV infection, or infection with hepatitis B or hepatitis C viruses according to protocolProtocolThe detailed plan a study must follow.Read more →-specific testing algorithm.
• −\- Medical Conditions:
• −Any of the following acute or chronic infections or infection history:
• −Active infection (including helminth or parasitic) requiring treatment within 2 weeks prior to screeningScreeningThe checks done before joining, to see whether a study fits.Read more →;
• −Infection requiring hospitalization or systemic (parenteral) antimicrobial therapy within 60 days prior to Day 1;
• −Active chronic or acute skin infection requiring treatment with systemic \[(not IV)\] antibiotics, antivirals, antiparasitics, antiprotozoals, or antifungals within 2 weeks prior to Day 1, or superficial skin infections (requiring no more than topical anti-infective treatments) within 1 week prior to Day 1.
• −Any infection judged to be an opportunistic infection or clinically significant by the investigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more →, within 6 months prior to Day 1;
• −History of or current evidence of inflammatory skin conditions (eg, psoriasis, seborrheic dermatitis, lupus) at the time of Day 1 that could interfere with evaluation of AD or response to treatment.
• −Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.
• −\- Prior/Concomitant Therapy:
• −Current use of any prohibited concomitant medication(s).
• −Phototherapy narrowband UVB (NB UVB) or broadband phototherapy or regular use (more than 2 visits per week) of a tanning booth/parlor within 4 weeks prior to Day 1.
• −\- Prior/Concurrent Clinical Study Experience:
• −Previous administration with an investigational product (drug or vaccine) within 30 days (or as determined by the local requirement) or 5 half lives preceding the first dose of study intervention used in this study (whichever is longer).
• −Evidence of active or latent TB, or inadequately treated infection with Mycobacterium TB. A participant who is currently being treated for active or latent TB infection must be excluded from this study.