Comparing 4 approaches for oxygen delivery
Official title: Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy
- 4 groups
- One site, in Québec
- Recruiting
Interventions (4)
- Medical device
Manual FiO2 titration with Philips oximeter (SpO2 target 90%)
FiO2 titration to reach the SpO2 target (set at 90%) with Philips oximeter
- Medical device
Manual FiO2 titration with Nonin oximeter (SpO2 target 90%)
FiO2 titration to reach the SpO2 target (set at 90%) with Nonin oximeter
- Medical device
Manual FiO2 titration with Philips oximeter (SpO2 target 94%)
FiO2 titration to reach the SpO2 target (set at 94%) with Philips oximeter
- Medical device
Manual FiO2 titration with Nonin oximeter (SpO2 target 94%)
FiO2 titration to reach the SpO2 target (set at 94%) with Nonin oximeter
Canadian Sites (1)
1 of 1 recruiting
- Recruiting
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
Québec, Quebec
Eligibility Criteria
See who this study is looking for9 criteria
The trial’s own eligibility text, word for word from the registry. Only the trial site can say who takes part.
Inclusion
- +Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter .
- +≥ 18 years of age
- +Admiitted in intensive care unit
- +Presence of an arterial catheter
Exclusion
- −No SpO2 signal with oximeter in use
- −False nails or nail polish
- −Methemoglobinemia \>0.015 on last available arterial gas
- −Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...)
- −Expected to use another respiratory support within two hour of inclusionInclusion criteriaThe things you must have or be for a study to consider you.Read more → (NIV or mechanical ventilation)
In plain language
Assembled directly from this trial’s registry record. Every sentence traces to a field below — nothing here is generated or interpreted.
What this study is
This study is testing a treatment for a condition.
This study is not organised into the usual phase numbers — that is common for device, behavioural, and diagnostic research.
From the trial registry
Built from these fields:
- designModule.designInfo.primaryPurpose
- designModule.phases
Who receives what
There are 4 groups in this study.
Group A receives Manual FiO2 titration with Nonin oximeter (SpO2 target 90%).
Registry label: A: Nonin oximeter with a 90% SpO2 target
Group B receives Manual FiO2 titration with Philips oximeter (SpO2 target 90%).
Registry label: B: Philips oximeter with a 90% SpO2 target
Group C receives Manual FiO2 titration with Nonin oximeter (SpO2 target 94%).
Registry label: C: Nonin oximeter with a 94% SpO2 target
Group D receives Manual FiO2 titration with Philips oximeter (SpO2 target 94%).
Registry label: D: Philips oximeter with a 94% SpO2 target
From the trial registry
Built from these fields:
- armsInterventionsModule.armGroups[].label
- armsInterventionsModule.armGroups[].type
- armsInterventionsModule.armGroups[].interventionNames
How the study is run
Which group you would be placed in is decided by chance, like a coin flip — not by you and not by your doctor.
One group of people involved — usually the participants — is not told which treatment is which.
From the trial registry
Built from these fields:
- designModule.designInfo.allocation
- designModule.designInfo.maskingInfo.masking
Is there a placebo?
This study does not list a placeboPlaceboA dummy treatment with no active medicine, used for comparison.Read more → group.
From the trial registry
Built from these fields:
- armsInterventionsModule.armGroups[].type
- armsInterventionsModule.armGroups[].interventionNames
Who the study is looking for
The study lists a minimum age of 18 years, with no upper limit given.
The study is open to people of any sex.
The study does not accept healthy volunteersHealthy volunteerSomeone without the condition being studied who takes part anyway.Read more →.
These are the criteria the study lists. Only the trial siteTrial siteA hospital or clinic where a study is actually run.Read more → can decide whether someone can take part.
From the trial registry
Built from these fields:
- eligibilityModule.minimumAge
- eligibilityModule.sex
- eligibilityModule.healthyVolunteers
How big and how long
The study aims to enrol about 30 people.
The study is currently expected to finish around December 2027.
The main measurement is taken over: Mean FiO2 in the two last minute of each study period between minute 8 and 10.
From the trial registry
Built from these fields:
- designModule.enrollmentInfo.count
- statusModule.completionDateStruct.date
- outcomesModule.primaryOutcomes[].timeFrame
What the study measures
FiO2 — measured over Mean FiO2 in the two last minute of each study period between minute 8 and 10.
From the trial registry
Built from these fields:
- outcomesModule.primaryOutcomes[].measure
- outcomesModule.primaryOutcomes[].timeFrame
Source: NCT07168213 on ClinicalTrials.gov. The full registry text is further down this page — this summary never replaces it.
Not medical advice. What do these terms mean?
What is being tested — in plain terms
About Manual FiO2 titration with Philips oximeter (SpO2 target 90%)Device
FiO2 titration to reach the SpO2 target (set at 90%) with Philips oximeter
From the trial registry — its own words, unedited.
What a device is here: A physical instrument, implant, app or piece of equipment being studied.
Read the full explanation → · in clinical review
About Manual FiO2 titration with Nonin oximeter (SpO2 target 90%)Device
FiO2 titration to reach the SpO2 target (set at 90%) with Nonin oximeter
From the trial registry — its own words, unedited.
What a device is here: A physical instrument, implant, app or piece of equipment being studied.
Read the full explanation → · in clinical review
About Manual FiO2 titration with Philips oximeter (SpO2 target 94%)Device
FiO2 titration to reach the SpO2 target (set at 94%) with Philips oximeter
From the trial registry — its own words, unedited.
What a device is here: A physical instrument, implant, app or piece of equipment being studied.
Read the full explanation → · in clinical review
About Manual FiO2 titration with Nonin oximeter (SpO2 target 94%)Device
FiO2 titration to reach the SpO2 target (set at 94%) with Nonin oximeter
From the trial registry — its own words, unedited.
What a device is here: A physical instrument, implant, app or piece of equipment being studied.
Read the full explanation → · in clinical review
Common questions
Answered from this trial’s registry record. Where the record doesn’t say, these answers say so rather than filling the gap.
Am I eligible for this trial?
Only the trial siteTrial siteA hospital or clinic where a study is actually run.Read more → can decide whether someone can take part. Concord cannot make that determination, and neither can any tool that has not examined you.
What the study lists: a minimum age of 18 years.
The full inclusionInclusion criteriaThe things you must have or be for a study to consider you.Read more → and exclusion criteriaExclusion criteriaThe things that would prevent someone from taking part.Read more → are published on this page, exactly as the study team wrote them.
The useful next step is to bring this trial to your doctor. Answering a few questions first gives them something concrete to review.
From the trial registry
- eligibilityModule.minimumAge
- eligibilityModule.eligibilityCriteria
Is there a placebo?
This study does not list a placeboPlaceboA dummy treatment with no active medicine, used for comparison.Read more → group.
From the trial registry
- armsInterventionsModule.armGroups[].type
Would I know which treatment I am getting?
One group of people involved — usually the participants — is not told which treatment is which.
Which group you would be placed in is decided by chance, like a coin flip — not by you and not by your doctor.
From the trial registry
- designModule.designInfo.maskingInfo.masking
- designModule.designInfo.allocation
Who can join?
The study lists a minimum age of 18 years, with no upper limit given.
It is open to people of any sex.
It does not accept healthy volunteersHealthy volunteerSomeone without the condition being studied who takes part anyway.Read more →.
Only the trial siteTrial siteA hospital or clinic where a study is actually run.Read more → can confirm whether a particular person can take part.
From the trial registry
- eligibilityModule.minimumAge
- eligibilityModule.sex
- eligibilityModule.healthyVolunteers
How long would this take?
The study's main measurement is taken over: Mean FiO2 in the two last minute of each study period between minute 8 and 10.
The study as a whole is currently expected to finish around 2027-12.
How long any one person takes part can differ from the study length. The study team can tell you what the schedule looks like in practice.
From the trial registry
- outcomesModule.primaryOutcomes[].timeFrame
- statusModule.completionDateStruct.date
How many people are taking part?
The study aims to enrol about 30 people.
From the trial registry
- designModule.enrollmentInfo.count
Where is this happening?
This study lists one location: Québec, Quebec, Canada.
Sites can open and close during a study, so confirm with the team before travelling.
From the trial registry
- trial_locations
About This Trial
Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target. It is essential to have an accurate measurement of SpO2 in order to optimize the flow of oxygen or FiO2 administered to patients. The question arises as to the impact of these confounding factors on the FiO2 set during high-flow nasal oxygen therapy. The aim of the study is to evaluate the impact of the oxygenation target and the oximeter used on FiO2 in patients receiving high-flow nasal oxygen therapy.
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See if this trial could fit youThis page is for informational purposes only and does not constitute medical advice. Clinical trial eligibility can only be determined by the trial site after proper screening. Trial information is sourced from ClinicalTrials.gov and may not reflect the most current status. Always consult your healthcare provider before making decisions about clinical trial participation.