Comparing Computerized speed-based cognitive with Computerized executive function for mild cognitive impairment

Exclusion

• −Potential participant has an existing diagnosis of major neurocognitive disorder at screeningScreeningThe checks done before joining, to see whether a study fits.Read more → (DSM-IV).
• −Potential participant who answered 'yes' to question 5 (Active Suicidal Ideation with Specific Plan and Intent) on the C-SSRS or 'yes' to any of the suicide-related behaviors (actual attempt, interrupted attempt, aborted attempt, preparatory act or behavior) on the C-SSRS "Suicidal Behavior" if the ideation or behavior occurred within 2 months from Participant's date of consentInformed consentThe process of being told what taking part involves, then choosing freely.Read more → (as recommended by the FDA for treatment trials.)
• −Potential participant scores \>10 on the Geriatric Depression Scale - Short Form (GDS-SF).
• −Potential participant has previously completed 10 or more hours of the computerized cognitive intervention program manufactured by Posit Science.
• −Potential participant is participating in a concurrent clinical trialInterventional studyA study where participants are given something to see what happens.Read more → (involving an investigational pharmaceutical, behavioral treatment, medical device or other) that, in the judgment of the investigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more →, could affect the outcome of this study.
• −Potential participant has claustrophobia or implantation with any medical devices above the waist that may concentrate radio frequency fields or have other medical issues that may frustrate participation in MRI/PET imaging procedures.
• −Potential participant has a history of large vessel stroke with significant residual motor or cognitive impairment.
• −Potential participant has a history of moderate to severe traumatic brain injury with residual cognitive symptoms.
• −Potential participant has a history of brain tumor.
• −Potential participant has a congestive heart failure diagnosis.
• −Potential participant has a primary diagnosis of idiopathic Parkinson's disease.
• −Potential participant has multiple sclerosis or Amyotrophic lateral sclerosis diagnosis.
• −Potential participant has evidence of a non-neurodegenerative neurological disorder that would interfere with the ability to carry out study activities.
• −Potential participant has has evidence of any other unstable medical conditions that would interfere with the ability to carry out study activities or cause fluctuations in cognition (for example, but not limited to, unstable diabetes, chronic obstructive pulmonary disorder dependent on oxygen).
• −Potential participant has any other clinically significant or unstable medical condition (for example, but not limited to, ongoing alcohol dependency or drug abuse, schizophrenia, psychosis) that in the investigator's opinion would interfere with the ability to carry out study activities.
• −Potential participant is pregnant or breastfeeding.
• −Potential participant is undergoing or plans to undergo surgery requiring anesthesia, chemotherapy, or radiation treatment in the six months following screening (can be rescreened and enrolledEnrolmentThe number of participants a study plans to include, or has included.Read more → later).