Testing CBD against a placebo for chronic migraine

Exclusion

• −Use of interventions or devices, such as nerve blocks, sphenopalatine ganglion blocks, vagal nerve stimulators, and transcranial magnetic stimulators during the baselineBaselineYour starting measurements, taken before treatment begins.Read more → period (weeks -4 to 0). These treatments will also be prohibited during the period of therapy (weeks 0 to 12).
• −Use of transitional therapies such as a course of steroids or a dihydroergotamine protocolProtocolThe detailed plan a study must follow.Read more → during the baseline period (weeks -4 to 0). These treatments will also be prohibited during the period of therapy (weeks 0 to 12).
• −Other active primary headaches, such as cluster headache, hemicrania continua, etc.
• −Any secondary headache, such as headache related to intracranial hypertension, intracranial hypotension, hydrocephalus, intracranial mass lesion, etc.
• −Active or significant history of major mental illness, including severe depression, or anxiety, and any history of psychosis or schizophrenia.
• −History of or current substance use disorder.
• −Regular use of cannabis for medical or recreational reasons during the previous 12 months.
• −History of significant cardiovascular or cerebrovascular disease, such as previous myocardial infarction, stroke, or peripheral vascular disease.
• −History of hypertension greater than 160/100 and not medically treated.
• −Any past history of seizure disorder.
• −Liver disease or liver enzymes two or more times the upper limit of normal at baseline.
• −Severe renal disease or GFR more than 30% below expected.
• −Any disorder or condition leading to hypersomnolence or excessive daytime drowsiness, such as narcolepsy, excessive use of sedatives/hypnotics, etc.
• −Any other medical condition that in the opinion of the investigators may pose a health risk to the subject if entered into the clinical trialInterventional studyA study where participants are given something to see what happens.Read more →.
• −Overuse of triptan, dihydroergotamine, opioid, or barbiturate medications, defined as 10 or more days per month in the 3 months prior to randomizationRandomisedWhich group you go into is decided by chance, not by you or your doctor.Read more →.
• −Overuse of simple analgesics (such as acetaminophen, ibuprofen, aspirin), and non-steroidal anti-inflammatories (such as naproxen, ketorolac, diclofenac, etc.) defined as 15 or more days per month in the 3 months prior to randomization.
• −Pregnant, planning to become pregnant, or breastfeeding.