Testing Navepegritide against a placebo for achondroplasia

Exclusion

• −Participant with serum 25-hydroxy-vitamin D (25OHD) levels of less than 30 nmol/L (less than 12 ng/mL) at Screening VisitScreeningThe checks done before joining, to see whether a study fits.Read more → will be excluded. Participants with 25OHD levels between 30-50 nmol/L (12-20 ng/mL) can be randomizedRandomisedWhich group you go into is decided by chance, not by you or your doctor.Read more → provided treatment with Vitamin D supplementation is initiated according to local standards.
• −Known or suspected hypersensitivity to the IMP or related products (trehalose, tris\[hydroxymethyl\]aminomethane, succinate, and mPEG).
• −Expected to require surgical intervention during participation in the trial that may significantly affect trial parameters (confounding of safety events) or would prevent the participant from performing trial procedures. Common surgeries, such as insertion of grommets, adenoidectomy, tonsillectomy, or myringotomy tube placement, are permitted.
• −Participation (signed informed consentInformed consentThe process of being told what taking part involves, then choosing freely.Read more →) in any interventionalInterventional studyA study where participants are given something to see what happens.Read more → clinical trial within 3 months prior to Screening unless no doses of IMP was given.
• −Decreased growth velocity (AGV less than 1.5 cm/year based on measurement over a period of at least 6 months) or radiological evidence of growth plate closure.
• −Have a growth disorder or medical condition other than ACH that results in short stature, or abnormal growth such as SADDAN, hypochondroplasia, growth hormone deficiency, Turner syndrome, pseudo-ACH, inflammatory bowel disease, celiac disease, hypothyroidism, hyperthyroidism, or diabetes mellitus.
• −Severe mutation in the FGFR3 gene, e.g. two variants on the same allele or severe ACH with developmental delay and acanthosis nigricans, are not eligible for trial participation.
• −Have received any dose of prescription medications and/or IMP (placeboPlaceboA dummy treatment with no active medicine, used for comparison.Read more → treatment only is allowed, if documented) or surgical intervention intended to affect stature, growth, or body proportionality at any time.
• −Requires, or anticipated to require, chronic (more than 4 weeks) or repeated treatment (more than twice/year and less than 3 weeks/year) with systemic corticosteroids during participation in the trial. Chronic use of high dose inhaled corticosteroids is not allowed.
• −Known history of presence of injury or disease of the growth plate(s), other than ACH, that affects growth potential of long bones.
• −Ventriculoperitoneal (VP) shunt and laminectomy with full recovery are allowed with minimum of 6 months of bone healing.
• −Bone fracture within 6 months prior to screening (within 2 months for fracture of digits and buckle fractures).
• −Clinically significant findings at Screening, such as:
• −Severe untreated sleep apnea or newly initiated sleep apnea treatment (e.g., Continuous Positive Airway Pressure \[CPAP\] in the previous 2 months prior to Screening.
• −MS disease, such as Salter-Harris fractures or clinical and/or radiographic evidence of severe hip pathology
• −Otherwise, are considered by the InvestigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more → to be unfit to receive trial treatment or undergo trial related procedures.
• −Have a clinically significant finding or arrhythmia as determined by the investigator in consultation with the medical monitor that indicates abnormal cardiac function or conduction that includes, but is not exclusive to:
• −Repaired or unrepaired coarctation.
• −Moderate or greater complexity congenital heart disease including tetralogy of Fallot, Atrioventricular septal defects, truncus arteriosus, total anomalous pulmonary venous return, double outlet right ventricle, or single ventricle heart disease.
• −QT corrected using Fridericia's correction (QTcF) ≥ 450 msec at Screening.
• −Known history or presence of condition that impacts hemodynamic stability (such as autonomic dysfunction and orthostatic intolerance).
• −Known history or presence of the following:
• −Chronic anemia (iron deficiency anemia that is resolved or adequately treated in the Investigator's opinion is allowed).
• −Chronic renal insufficiency defined as estimated glomerular filtration rate (eGFR) according to the revised bedside Schwartz equation less than 60 mL/min/1.73 m2 for more than 3 months.
• −Chronic or recurrent illness that can affect hydration or volume status, including conditions associated with decreased nutritional intake or increased volume loss.
• −Known history or presence of malignant disease.
• −Any disease or condition that, in the opinion of the Investigator, may make the participant unlikely to fully complete the trial, may confound interpretation of trial results, or may present undue risk from receiving trial treatment. This could include family situations, complications or manifestations, or medications that might impact safety or be considered confounding.
• −Sexually active male and female participants and female partners of male participants of childbearing potential not using a highly effective form of contraceptive for the entire trial period and for 90 days after last dose of trial treatment.
• −Female participants who are pregnant, lactating or breastfeeding.
• −Known history of any bone-related surgery affecting growth potential of long bones, such as:
• −Orthopedic reconstructive surgery for bone lengthening (e.g., procedures for leg bowing such as 8-plate are not exclusionary).