Testing Brivekimig against a placebo for hidradenitis suppurativa

Exclusion

• −A history of an Adverse EventAdverse eventAny medical problem that happens during a study, whether or not the treatment caused it.Read more → (AE) attributed to or related to anti-TNF therapy (examples include, but are not limited, to serum sickness or anaphylaxis) for an HS or non-HS indication that would contraindicate readministration of an anti-TNF class therapy
• −Sensitivity to any of the study interventions, or components thereof, or drug or other allergy that, in the opinion of the InvestigatorPrincipal investigatorThe doctor or researcher responsible for running the study at a site.Read more →, contraindicates participation in the study
• −Participants are excluded from the study if any of the following criteria apply:
• −Any other active skin disease or condition (eg, bacterial, fungal, or viral infection) that may interfere with assessment of HS
• −History of recurrent or recent serious infection
• −Known history of significant immunosuppression
• −History of solid organ transplant or stem cell transplant
• −History of splenectomy
• −History of moderate to severe congestive heart failure.
• −History of demyelinating disease (including myelitis) or neurologic symptoms suggestive of demyelinating disease
• −Participants with a history of malignancy or lymphoproliferative disease other than adequately treated or nonmetastatic squamous cell carcinoma of the skin that was excised and completely cured or nonmetastatic basal cell carcinoma of the skin that was excised and completely cured
• −History of any other condition which, in the opinion of the Investigator, would put the participant at risk by participation in the protocolProtocolThe detailed plan a study must follow.Read more →
• −Active suicidality and therefore significant suicide risk, as judged by the Investigator
• −History (within last 2 years prior to Baseline visitBaselineYour starting measurements, taken before treatment begins.Read more →) of prescription drug or substance abuse, including alcohol, considered significant by the Investigator
• −The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trialInterventional studyA study where participants are given something to see what happens.Read more →.